Azulfidine | Sulfasalazine Tablet while Breastfeeding

Breast milk is superior in nutrition, It provides resistance against infections and allergies, It is naturally sterile. Despite all the advantages of breastfeeding some mothers choose to pause the breastfeeding in fear of harmful effects of medicines passing in breast milk. Are you wondering about breastfeeding and using Azulfidine | Sulfasalazine Tablet ? Know what is Azulfidine | Sulfasalazine Tablet and how it can affect your breast milk and whether Azulfidine | Sulfasalazine Tablet is safe for your kid or not.

What is Azulfidine | Sulfasalazine Tablet used for?

AZULFIDINE Tablets are indicated: a)in the treatment of mild to moderate ulcerative colitis, and as adjunctive therapy in severe ulcerative colitis; and b)for the prolongation of the remission period between acute attacks of ulcerative colitis.

Azulfidine | Sulfasalazine Tablet while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Azulfidine | Sulfasalazine Tablet safe for breastfeeding
Active ingredient in Azulfidine | Sulfasalazine Tablet is Sulfasalazine and based on our analysis of Sulfasalazine it appears that using Azulfidine | Sulfasalazine Tablet is safe in breastfeeding. Below is analysis of Sulfasalazine while breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers Caution should be exercised when AZULFIDINE is administered to a nursing woman. Sulfonamides are excreted in the milk. In the newborn, they compete with bilirubin for binding sites on the plasma proteins and may thus cause kernicterus. Insignificant amounts of uncleaved sulfasalazine have been found in milk, whereas the sulfapyridine levels in milk are about 30 to 60 percent of those in the maternal serum. Sulfapyridine has been shown to have a poor bilirubin-displacing capacity. There have been reports of bloody stools or diarrhea in infants who were breastfeeding from mothers on sulfasalazine. In cases where the outcome was reported, bloody stools or diarrhea resolved in the infant after discontinuation of sulfasalazine in the mother.

Azulfidine | Sulfasalazine Tablet Breastfeeding Analsys

Sulfasalazine while Breastfeeding


CAS Number: 599-79-1

Prodrug of Mesalazine: medication compounded by union of Sulfapyridine and 5-ASA which is degraded into Mesalazine by bacteria in the large intestine. Mesalazine is badly absorbed by the intestine, serum levels are low with scant excretion into breast milk. Inactive metabolite N-acetyl-5-ASA was found in small amount in the milk with a relative infant dose not higher than 10%. No harm effects among breastfed infants from treated mothers have been reported, except for rare cases of diarrhea reported in the 80's with the use of Sulfasalazine. In a review of 121 cases and 121 controls, the authors failed to observe those findings. (Moretti, 1989). Expert consensus supports the compatibility of Mesalazine and/or its prodrugs during breastfeeding. Sulfapyridine released in the large intestine is 60% absorbed with a protein-binding capacity of 90%, both being a reason for low excretion into breast milk. Mesalazine derivatives that not contain Sulfapyridine are recommended by some authors for use while breastfeeding (see alternative drugs).

Azulfidine | Sulfasalazine Tablet Breastfeeding Analsys - 2

Sulfasalazine while Breastfeeding

CAS Number: 599-79-1

Azulfidine | Sulfasalazine Tablet and breastfeeding

Sulfasalazine and its active metabolite mesalamine are poorly excreted into breastmilk. However, rather high levels of the mesalamine metabolite N-acetyl-5-ASA appear in breastmilk and its effects on breastfed infants are unknown. Another sulfasalazine metabolite, sulfapyridine, also appears in milk and infant serum and might cause hemolysis, especially in newborn infants and in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The time of greatest risk for hemolysis in fullterm newborns without G6PD deficiency might be as short as 8 days after birth.[1] Bloody diarrhea has occurred in an infant whose mother was taking sulfasalazine and a few cases of diarrhea have been reported in infants exposed to mesalamine in breastmilk, although the rate is not high. Most experts consider mesalamine derivatives to be safe during breastfeeding.[2][3][4][5][6][7] If sulfasalazine is required by the mother, it is not a reason to discontinue breastfeeding, but carefully observe breastfed infants for diarrhea. Other mesalamine derivatives that do not contain a sulfonamide are preferred.

Is Azulfidine | Sulfasalazine Tablet safe while breastfeeding

What if I already have used Azulfidine | Sulfasalazine Tablet?

It is always a good idea to keep your healthcare provider or doctor informed about your drug usage during pregnancy and breastfeeding but if you have not informed your doctor about Azulfidine | Sulfasalazine Tablet and have used it then do not panic as Azulfidine | Sulfasalazine Tablet is mostly safe in breastfeeding and should not cause any harm to your baby.

I am nursing mother and my doctor has suggested me to use Azulfidine | Sulfasalazine Tablet, is it safe?

Definitely, Azulfidine | Sulfasalazine Tablet is safe in lactation for baby. No wonder your doctor has recommended it.

If I am using Azulfidine | Sulfasalazine Tablet, will my baby need extra monitoring?

No extra baby monitoring required while mother is using Azulfidine | Sulfasalazine Tablet

Who can I talk to if I have questions about usage of Azulfidine | Sulfasalazine Tablet in breastfeeding?

National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week