Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release while Breastfeeding

Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release Breastfeeding

Do you know that important immune protective proteins are present in breast milk? Breast milk also contains required vitamins, minerals, saturated and un saturated fats. These things are extremely important for development of healthy brain. If you are taking any medicine for short term or for the chronic reason then that passes in breast milk as well, that is why you should always check the drug with your health care provider. Here at DrLact we try to analyze drugs based on available researches and in this sheet we will present our analysis for Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release.

What is Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release ?

Bupropion hydrochloride extended-release tablets (XL) is an aminoketone antidepressant, indicated for the treatment of major depressive disorder (MDD) and prevention of seasonal affective disorder (SAD). Periodically reevaluate long-term usefulness for the individual patient. (1) 1.1 Major Depressive Disorder Bupropion hydrochloride extended-release tablets (XL) is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). The efficacy of the immediate-release formulation of bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. The efficacy of the sustained-release formulation of bupropion in the maintenance treatment of MDD was established in a long-term (up to 44 weeks), placebo-controlled trial in patients who had responded to bupropion in an 8-week study of acute treatment [see Clinical Studies(14.1)]. 1.2 Seasonal Affective Disorder Bupropion hydrochloride extended-release tablets (XL) is indicated for the prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD). The efficacy of bupropion hydrochloride extended-release tablets in the prevention of seasonal major depressive episodes was established in 3 placebo-controlled trials in adult outpatients with a history of MDD with an autumn-winter seasonal pattern as defined in the DSM [see Clinical Studies(14.2) ].

Can I use Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release while breastfeeding?

Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release low risk for breastfeeding

Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release contains only one active ingredient that is Bupropion hydrochloride. We have analyzed the usage of Bupropion hydrochloride in breastfeeding and our analysis suggest that Bupropion hydrochloride poses Low risk for infant while breastfeeding and hence Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release itself shall be considered Low risk item for breastfeeding.

Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release Breastfeeding Analsys

Bupropion hydrochloride while Breastfeeding

Low Risk

CAS Number: 34911-55-2

Selective inhibitor of the neuronal reuptake of catecholamines (noradrenaline and dopamine). It is used as an antidepressant and to help stop smoking (Baraona 2017). Administered orally, one daily dose. Although the concentration in milk is much higher than the plasma concentration, it is excreted in breast milk in very small amounts (Neuman 2014, Davis 2009, Haas 2004, Briggs 1993). The plasma levels of infants whose mothers were taking it were undetectable or very low (Neuman 2014, Davis 2009, Baab 2002, Briggs 1993). Given the negligible excretion in milk, the absence of plasma levels in infants and the fact that no problems were observed in infants in several publications (Nonacs 2005, Baab 2002, Briggs 1993), two cases of seizures in infants whose mothers were taking bupropion are difficult to explain, whether in monotherapy (Chaudron 2004) or associated with other antidepressants (Neuman 2014). Progress was satisfactory. Bupropion does not alter prolactin levels (Whiteman 1982). Avoid in mothers with a history of epilepsy since it decreases the seizure threshold. Until there is more published data on this drug in relation to breastfeeding, safer alternatives known may be preferable (Sriraman 2015, Carson 2013, Berle 2011, Davanzo 2011), especially during the neonatal period and in case of prematurity. See below the information of these related products:

Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release Breastfeeding Analsys - 2

Bupropion hydrochloride while Breastfeeding

CAS Number: 34911-55-2

Limited information indicates that maternal bupropion doses of up to 300 mg daily produce low levels in breastmilk and would not be expected to cause any adverse effects in breastfed infants. However, there is little reported use in breastfed newborn infants and case reports of a possible seizure in partially breastfed 6-month-olds. If bupropion is required by a nursing mother, it is not a reason to discontinue breastfeeding. However, another drug may be preferred, especially while nursing a newborn or preterm infant. Infants exposed to bupropion and an SSRI through breastfeeding should be closely monitored for vomiting, diarrhea, jitteriness, or sedation and possibly measurement of serum levels to rule out toxicity if there is a concern.

I already used Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release and meanwhile I breastfed my baby should I be concerned?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release then you shall inform your doctor, But you should not be worried too much as Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release comes in category of low risk drug.

My doctor has prescribed me Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release, what should I do?

Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.

If I am using Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release, will my baby need extra monitoring?

Not much

Who can I talk to if I have questions about usage of Bupropion Hydrochloride (xl) | Bupropion Hydrochloride Tablet, Extended Release in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week