It is a well known fact that breastfeeding is best source of nutrition for infants. Breast milk provides minerals, vitamins and antibodies in most acceptable format when they need it. Nutrition taken by mother passes to breast-milk and same thing applies to medicines taken by mothers. Not all drugs cause problem for baby but some do. Lets analyze if Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet is safe for baby while breastfed.
Darvocet A500 contains propoxyphene napsylate and acetaminophen. Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a bitter taste. It is very slightly soluble in water and soluble in methanol, ethanol, chloroform, and acetone. Chemically, it is (α S, 1 R)-α-[ 2-(Dimethylamino)-1-methylethyl ] -α-phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate, which can be represented by the accompanying structural formula. Its molecular weight is 565.72. Propoxyphene napsylate differs from propoxyphene hydrochloride in that it allows more stable liquid dosage forms and tablet formulations. Because of differences in molecular weight, a dose of 100 mg (176.8 μmol) of propoxyphene napsylate is required to supply an amount of propoxyphene equivalent to that present in 65 mg (172.9 μmol) of propoxyphene hydrochloride. Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2 and the molecular weight is 151.17. It may be represented by the following structural formula: Each tablet of Darvocet A500® contains 100 mg (176.8 μmol) propoxyphene napsylate and 500 mg (3307.8 μmol) acetaminophen. Each tablet also contains anhydrous lactose, colloidal silicon dioxide, crospovidone, magnesium stearate (powder), microcrystalline cellulose, povidone, pregelatinized corn starch, and stearic acid (powder). Film coating composed of: carnauba wax, hypromellose 2910 6cP, polyethylene glycol, purified water, sodium citrate, titanium dioxide, FD&C Red No. 40 Aluminum Lake, and FD&C Yellow No. 6 Aluminum Lake. Structural Formula Structural Formula
Can I continue breastfeeding if I am using Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet? How long does it stays in breast milk?
There are 2 main ingredients of Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet, Propoxyphene napsylate and Acetaminophen. One by one we have analyzed both Propoxyphene napsylate and Acetaminophen for its impact on breastfeeding and based on our analysis we can conclude that Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet is safe to use in breastfeeding. We recommend you to check our analysis of Propoxyphene napsylate and Acetaminophen as below.
Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers Propoxyphene, norpropoxyphene (major metabolite), and acetaminophen are excreted in human milk. Published studies of nursing mothers using propoxyphene detected no adverse effects in nursing infants. Based on a study of six mother-infant pairs, an exclusively breastfed infant receives approximately 2% of the maternal weight-adjusted dose. Norpropoxyphene is renally excreted and renal clearance is lower in neonates than in adults. Therefore, it is possible that prolonged maternal propoxyphene use could result in norpropoxyphene accumulation in a breastfed infant. Watch breastfeeding infants for signs of sedation including poor feeding, somnolence, or respiratory depression. Caution should be exercised when Darvocet A500 is administered to a nursing woman.
Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet Breastfeeding Analsys
Propoxyphene napsylate while Breastfeeding Safe
CAS Number: 469-62-5
We are working on a comment for this product.
Acetaminophen while Breastfeeding Safe
CAS Number: 103-90-2
Excreted in very low amount into breast milk. Infant intake may be lower than 4% of usual pediatric dose. The American Academy of Pediatrics rates it as compatible with Breastfeeding.
Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet Breastfeeding Analsys - 2
Propoxyphene napsylate while Breastfeeding
CAS Number: 469-62-5
Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system depression and even death. Newborn infants seem to be particularly sensitive to the effects of even small dosages of propoxyphene may be particularly prone to causing these effects. Propoxyphene should be avoided during breastfeeding.
Acetaminophen while Breastfeeding
CAS Number: 103-90-2
Acetaminophen is a good choice for analgesia, and fever reduction in nursing mothers. Amounts in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare.
What should I do if already breastfed my kid after using Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet?
Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet is safe in breastfeeding and should not create any health problem for your baby but in case you feel any health issue associated with Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet you should contact your doctor or health care provider. Be it pregnancy or lactation you shall keep your doctor informed.
My doctor has prescribed me Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet, what should I do?
Definitely, Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet is safe in lactation for baby. No wonder your doctor has recommended it.
If I am using Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet, will my baby need extra monitoring?
No extra baby monitoring required while mother is using Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet
Who can I talk to if I have questions about usage of Darvocet A500 | Propoxyphene Napsylate And Acetaminophen Tablet in breastfeeding?
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week