Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. Breastfeeding
Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. is safe in breast-feeding or not.

What is Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. used for?


Amiodarone Hydrochloride Injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Amiodarone also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. During or after treatment with amiodarone, patients may be transferred to oral amiodarone therapy (see DOSAGE AND ADMINISTRATION). Amiodarone HCl Injection should be used for acute treatment until the patient's ventricular arrhythmias are stabilized. Most patients will require this therapy for 48 to 96 hours, but amiodarone may be safely administered for longer periods if necessary.

Is Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. safe to use while breastfeeding? Can it interfere with growth and development of my kid?

Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. high risk while breastfeeding
As Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. is made of only Amiodarone hydrochloride, and Amiodarone hydrochloride is unsafe to use in breastfeeding we can safely reach on conclusion that Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. is also unsafe to use while breastfeeding. Below is detailed analysis of Amiodarone hydrochloride and Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. during location. We recommend you to go through provided detailed analysis as below take decision accordingly. We also recommend you talk to your health care provider before making final decision.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers ‚Äč Amiodarone and one of its major metabolites, desethylamiodarone (DEA), are excreted in human milk, suggesting that breast-feeding could expose the nursing infant to a significant dose of the drug. Nursing offspring of lactating rats administered amiodarone have demonstrated reduced viability and reduced body weight gains. The risk of exposing the infant to amiodarone should be weighed against the potential benefit of arrhythmia suppression in the mother. The mother should be advised to discontinue nursing.

Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. Breastfeeding Analsys


Amiodarone hydrochloride while Breastfeeding

Unsafe

CAS Number: 1951-25-3

A published case of infant hypothyroidism. Others have reported lab controlled cases with harmless effect in breastfed babies.


Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. Breastfeeding Analsys - 2


Amiodarone hydrochloride while Breastfeeding

CAS Number: 1951-25-3

Breastmilk and infant serum levels of amiodarone and its active metabolite are somewhat unpredictable, but can be high during breastfeeding. The infant receives an estimated dose of amiodarone plus desethylamiodarone ranging from 3.5 to 45% of the mother's weight-adjusted amiodarone dose, with a median dose of about 11%.[1][2][3][4] Infant serum levels of the drug plus metabolite range from 14 to 74% of simultaneous maternal levels, with the higher values reflecting transplacental passage of the drug.[2][3][4] In addition to possible cardiac effects, these compounds contain a large amount of iodine which may be released during metabolism. Thyroid dysfunction was reported in one breastfed infant. Even if the drug were discontinued at birth, the mother would continue to excrete amiodarone and its metabolite (and possibly large amounts of iodine) into breastmilk for days to weeks. Some investigators believe that breastfeeding can be undertaken during maternal amiodarone use with periodic monitoring of infant cardiac and thyroid function status,[5][6] especially if only a single dose of amiodarone is given.[7] Infant serum levels of amiodarone and desethylamiodarone may be useful for ruling out cardiac effects of the drug. If hypothyroidism develops, therapy should be promptly initiated.


Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. and breastfeeding

I am nursing mother and I have already used Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc., what should I do?

If you observer abnormal behavior or any other health issue in infant then you should immediately call 911 or contact other contact other emergency service provider in your area otherwise closely monitor the baby and inform your doctor about your Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. usage and time interval of breastfeeding.


My health care provider has asked me to use Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc., what to do?

If your doctor knows that you are breastfeeding mother and still prescribes Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. then there must be good reason for that as Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. is considered unsafe, It usually happens when doctor finds that overall advantage of taking outweighs the overall risk.


If I am using Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc., will my baby need extra monitoring?

Yes, Extra monitoring is required if mother is using Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. and breastfeeding as it is considered unsafe for baby.


Who can I talk to if I have questions about usage of Amiodarone Hydrochloride | Amphastar Pharmaceuticals, Inc. in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week