Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs while Breastfeeding

Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs Breastfeeding

Nutrients from the food that you eat passes to your breast milk. Its good idea to take healthy diet while breastfeeding. You may need to consume more calories per day to support healthy body system. Some time it gets necessary take medicine while you are breastfeeding and as other food items passes into breast milk, medicine passes as well hence it becomes obvious to understand its effects while breastfeeding. We have analyzed many medications and in this sheet we will present some fact and known information associated with Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs while breast-feeding.

What is Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs ?

Bupropion hydrochloride extended-release tablet, (XL) is an aminoketone antidepressant, indicated for the treatment of major depressive disorder (MDD) and prevention of seasonal affective disorder (SAD). Periodically reevaluate long-term usefulness for the individual patient. (1) 1.1 Major Depressive Disorder Bupropion hydrochloride extended-release tablets, (XL) are indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). The efficacy of the immediate-release formulation of bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. The efficacy of the sustained-release formulation of bupropion in the maintenance treatment of MDD was established in a long-term (up to 44 weeks), placebo-controlled trial in patients who had responded to bupropion in an 8-week study of acute treatment [see Clinical Studies (14.1) ]. 1.2 Seasonal Affective Disorder Bupropion hydrochloride extended-release tablets, (XL) are indicated for the prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD). The efficacy of bupropion hydrochloride extended-release tablets, (XL) in the prevention of seasonal major depressive episodes was established in 3 placebo-controlled trials in adult outpatients with a history of MDD with an autumn-winter seasonal pattern as defined in the DSM [see Clinical Studies (14.2) ].

Is using Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs safe or dangerous while breastfeeding?

Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs low risk for breastfeeding

Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs contains only one active ingredient that is Bupropion hydrochloride. We have analyzed the usage of Bupropion hydrochloride in breastfeeding and our analysis suggest that Bupropion hydrochloride poses Low risk for infant while breastfeeding and hence Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs itself shall be considered Low risk item for breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Bupropion and its metabolites are present in human milk. In a lactation study of ten women, levels of orally dosed bupropion and its active metabolites were measured in expressed milk. The average daily infant exposure (assuming 150 mL/kg daily consumption) to bupropion and its active metabolites was 2% of the maternal weight-adjusted dose. Exercise caution when bupropion is administered to a nursing woman.

Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs Breastfeeding Analsys

Bupropion hydrochloride while Breastfeeding

Low Risk

CAS Number: 34911-55-2

Selective inhibitor of the neuronal reuptake of catecholamines (noradrenaline and dopamine). It is used as an antidepressant and to help stop smoking (Baraona 2017). Administered orally, one daily dose. Although the concentration in milk is much higher than the plasma concentration, it is excreted in breast milk in very small amounts (Neuman 2014, Davis 2009, Haas 2004, Briggs 1993). The plasma levels of infants whose mothers were taking it were undetectable or very low (Neuman 2014, Davis 2009, Baab 2002, Briggs 1993). Given the negligible excretion in milk, the absence of plasma levels in infants and the fact that no problems were observed in infants in several publications (Nonacs 2005, Baab 2002, Briggs 1993), two cases of seizures in infants whose mothers were taking bupropion are difficult to explain, whether in monotherapy (Chaudron 2004) or associated with other antidepressants (Neuman 2014). Progress was satisfactory. Bupropion does not alter prolactin levels (Whiteman 1982). Avoid in mothers with a history of epilepsy since it decreases the seizure threshold. Until there is more published data on this drug in relation to breastfeeding, safer alternatives known may be preferable (Sriraman 2015, Carson 2013, Berle 2011, Davanzo 2011), especially during the neonatal period and in case of prematurity. See below the information of these related products:

Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs Breastfeeding Analsys - 2

Bupropion hydrochloride while Breastfeeding

CAS Number: 34911-55-2

Limited information indicates that maternal bupropion doses of up to 300 mg daily produce low levels in breastmilk and would not be expected to cause any adverse effects in breastfed infants. However, there is little reported use in breastfed newborn infants and case reports of a possible seizure in partially breastfed 6-month-olds. If bupropion is required by a nursing mother, it is not a reason to discontinue breastfeeding. However, another drug may be preferred, especially while nursing a newborn or preterm infant. Infants exposed to bupropion and an SSRI through breastfeeding should be closely monitored for vomiting, diarrhea, jitteriness, or sedation and possibly measurement of serum levels to rule out toxicity if there is a concern.

I am nursing mother and I have already used Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs, what should I do?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs then you shall inform your doctor, But you should not be worried too much as Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs comes in category of low risk drug.

My doctor has prescribed me Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs, what should I do?

Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.

If I am using Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs, will my baby need extra monitoring?

Not much

Who can I talk to if I have questions about usage of Bupropion Hydrochloride (xl) | Ncs Healthcare Of Ky, Inc Dba Vangard Labs in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week