Perphenazine And Amitriptyline Hydrochloride Tablet while Breastfeeding

What is Perphenazine And Amitriptyline Hydrochloride Tablet used for?

Is using Perphenazine And Amitriptyline Hydrochloride Tablet unsafe in breastfeeding? Can there be bad consequences for baby if I use it while breastfeeding?

Perphenazine while Breastfeeding

CAS Number: 58-39-9

One reportedly case of use by a mother for 3,5 months (8 - 12 mg x 2 / daily) without harm effects on the child. Check-up for lethargy or dyskinetic symptoms.

Amitriptyline hydrochloride while Breastfeeding

CAS Number: 50-48-6

It is excreted into breastmilk in a clinically non-significant amount (Bader 1980, Brixen 1982, Pittard 1986, Breyer 1995, Yoshida 1999). Plasma levels in the infant have been found undetectable (Ericsson 1979, Bader 1980, Brixen 1982, Breyer 1995) or very low (Yoshida 1997) and no side effects being observed even at maternal doses as high as 150-175 mg / day (Brixen 1982 , Misri 1991, Yoshida 1999, Nulman 2002).However, one published case of sedation on a 15-day-old infant that occured within few days after taken just 10 mg daily of amitriptyline by her mother because of insomnia and anxiety (Oguz 2016). Levels were not measured in either milk or plasma of the infant and the mother. Amitriptyline may produce galactorrhoea by prolactin stimulation.

Perphenazine while Breastfeeding

CAS Number: 58-39-9

Limited information indicates that maternal doses of perphenazine up to 24 mg daily produce low levels in milk. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Monitor the infant for excessive drowsiness during breastfeeding and for developmental milestones, especially if other antipsychotics are used concurrently.

Amitriptyline hydrochloride while Breastfeeding

CAS Number: 50-48-6

Milk levels of amitriptyline and its metabolites are low. Immediate side effects have not been reported and a limited amount of follow-up has found no adverse effects on infant growth and development. Amitriptyline use during breastfeeding would usually not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. However, rare sedation has been reported in a neonate. Other agents with fewer active metabolites may be preferred when large doses are required or while nursing a newborn or preterm infant.

I already used Perphenazine And Amitriptyline Hydrochloride Tablet and meanwhile I breastfed my baby should I be concerned?

My health care provider has asked me to use Perphenazine And Amitriptyline Hydrochloride Tablet, what to do?

If I am using Perphenazine And Amitriptyline Hydrochloride Tablet, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Perphenazine And Amitriptyline Hydrochloride Tablet in breastfeeding?