Colchicine Capsule while Breastfeeding
What is Colchicine Capsule used for?
Is Colchicine Capsule usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?
8.3 Use in Nursing Mothers Colchicine is excreted into human milk. Limited information suggests that infants exclusively breastfed receive less than 10 percent of the maternal weight-adjusted dose. While there are no published reports of adverse effects in breast-feeding infants of mothers taking colchicine, colchicine can affect gastrointestinal cell renewal and permeability. Caution should be exercised and breastfeeding infants should be observed for adverse effects when colchicine capsules is administered to a nursing woman.
Colchicine Capsule Breastfeeding Analsys
Colchicine while Breastfeeding
Low RiskCAS Number: 64-86-8
It is used for treatment of Gout, Familial Mediterranean Fever. As well as for other conditions like Amyloidosis, Behçet's Syndrome, Pericarditis, Primary Biliary Cirrhosis and Pyoderma gangrenosum. It is excreted in breast milk in quantities that differ according to different published studies, from no clinically significant in some, until being important in others, but there have been no problems in infants whose mothers were treated, even after months, with undetectable plasma levels in these infants. The concomitant use of macrolide antibiotics and fruit juices (both the mother and the infant) , especially grape-fruit, is not recommended since they may interfere with bile excretion and greatly increase toxicity. The American Academy of Breastfeeding rates it as compatible with breastfeeding. List of Essential Medicines of WHO (2002): compatible with breastfeeding
Colchicine Capsule Breastfeeding Analsys - 2
Colchicine while Breastfeeding
CAS Number: 64-86-8
Long-term prophylactic maternal doses of colchicine up to 1.5 mg daily produce levels in milk that result in the infant receiving less than 10% of the maternal weight-adjusted dosage. The highest milk levels occur 2 to 4 hours after a dose, so avoiding breastfeeding during this time can minimize the infant dose, although some clinicians simply recommend taking the drug after nursing. No adverse effects in breastfed infants have been reported in case series and a case-control study and some authors consider colchicine safe during breastfeeding in women being treated for familial Mediterranean fever or rheumatic conditions.[1][2][3][4]
I am nursing mother and I have already used Colchicine Capsule, what should I do?
Colchicine Capsule is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Colchicine Capsule so you should inform him based on your convenience.
I am nursing mother and my doctor has suggested me to use Colchicine Capsule, is it safe?
Though Colchicine Capsule dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.
If I am using Colchicine Capsule, will my baby need extra monitoring?
Not much monitoring required while using Colchicine Capsule
Who can I talk to if I have questions about usage of Colchicine Capsule in breastfeeding?
US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week