Propylthiouracil Tablet Breastfeeding
Breast milk is superior in nutrition, It provides resistance against infections and allergies, It is naturally sterile. Despite all the advantages of breastfeeding some mothers choose to pause the breastfeeding in fear of harmful effects of medicines passing in breast milk. Are you wondering about breastfeeding and using Propylthiouracil Tablet ? Know what is Propylthiouracil Tablet and how it can affect your breast milk and whether Propylthiouracil Tablet is safe for your kid or not.

What is Propylthiouracil Tablet used for?


: Propylthiouracil is indicated: in patients with Graves' disease with hyperthyroidism or toxic multinodular goiter who are intolerant of methimazole and for whom surgery or radioactive iodine therapy is not an appropriate treatment option. to ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy in patients who are intolerant of methimazole.

Is Propylthiouracil Tablet usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Propylthiouracil Tablet safe for breastfeeding
Propylthiouracil is the only one ingredient used in manufacturing of Propylthiouracil Tablet, Which makes it easier to analyze its effect in breastfeeding. As per our analysis of Propylthiouracil it is safe to use Propylthiouracil Tablet while lactating. We suggest you to check further details below about Propylthiouracil usage in breastfeeding.

Propylthiouracil Tablet Breastfeeding Analsys


Propylthiouracil while Breastfeeding

Safe

CAS Number: 51-52-5

Small amount of Propylthiouracil can reach the breast milk but it doesn't cause harm to the thyroid function (Low 1979, Kampmann 1980, Cooper 1987). The American Thyroid Association among others (Mandel 2001, Stagnaro 2011, Alexander 2017) stated that a daily dose as high as 450 mg is safe while breastfeeding. However, some studies have shown no harmful effect at a daily dose as high as 750 mg (Kampmann 1980, McDougall 1986, Cooper 1987, Momotani 1989 y 2000, Bartalena 2005, Azizi 2006, Marx 2008, Inoue 2009, Glatstein 2009). Methimazole or Carbimazole is preferred since liver toxicity has been found among patients who were treated with Propylthiouracil (Karras 2009, 2010 y 2012, Azizi 2011, Serrano 2014, Hudzik 2016). The American Academy of Pediatrics has rated it (2001) as compatible with breastfeeding. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.


Propylthiouracil Tablet Breastfeeding Analsys - 2


Propylthiouracil while Breastfeeding

CAS Number: 51-52-5

Propylthiouracil (PTU) had been considered the antithyroid drug of choice during lactation;[1][2] however, findings that the rates of liver injury higher with PTU than with methimazole has altered this judgement.[3] Some experts now recommend that methimazole should be considered the antithyroid drug of choice in nursing mothers.[4][5] No cases of PTU-induced liver damage have been reported in breastfed infants and it is unknown if the small amounts of the drug in breastmilk can cause liver damage. The drug or breastfeeding should be discontinued if liver toxicity is suspected. Dosages of PTU should be limited to 450 mg daily during breastfeeding.[6] The American Thyroid Association recommends only monitoring infants for appropriate growth and development during routine pediatric health and wellness evaluations and routine assessment of serum thyroid function in the child is not recommended.[6] Rare idiosyncratic reactions (e.g., agranulocytosis) might occur, and the infant should be watched for signs of infection. Monitoring of the infant's complete blood count and differential is advisable if there is a suspicion of a drug-induced blood dyscrasia.



What if I already have used Propylthiouracil Tablet?

As usage of Propylthiouracil Tablet is mostly safe while breastfeeding hence there should not be any concern. In case of any change in behavior or health of your baby you should inform your health care provider about usage of Propylthiouracil Tablet else no further action is required.


I am nursing mother and my doctor has suggested me to use Propylthiouracil Tablet, is it safe?

Definitely, Propylthiouracil Tablet is safe in lactation for baby. No wonder your doctor has recommended it.


If I am using Propylthiouracil Tablet, will my baby need extra monitoring?

No extra baby monitoring required while mother is using Propylthiouracil Tablet


Who can I talk to if I have questions about usage of Propylthiouracil Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week