Ketoconazole Cream Breastfeeding

Nutrients from the food that you eat passes to your breast milk. Its good idea to take healthy diet while breastfeeding. You may need to consume more calories per day to support healthy body system. Some time it gets necessary take medicine while you are breastfeeding and as other food items passes into breast milk, medicine passes as well hence it becomes obvious to understand its effects while breastfeeding. We have analyzed many medications and in this sheet we will present some fact and known information associated with Ketoconazole Cream while breast-feeding.

What is Ketoconazole Cream used for?

Ketoconazole cream, 2% is indicated for the topical treatment of tinea corporis, tinea cruris and tinea pedis caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum; in the treatment of tinea (pityriasis) versicolor caused by Malassezia furfur (Pityrosporum orbiculare); in the treatment of cutaneous candidiasis caused by Candida spp. and in the treatment of seborrheic dermatitis.

Is Ketoconazole Cream usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Ketoconazole Cream safe for breastfeeding
Active ingredient in Ketoconazole Cream is Ketoconazole and based on our analysis of Ketoconazole it appears that using Ketoconazole Cream is safe in breastfeeding. Below is analysis of Ketoconazole while breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers It is not known whether Ketoconazole cream, 2% administered topically could result in sufficient systemic absorption to produce detectable quantities in breast milk. Nevertheless, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Ketoconazole Cream Breastfeeding Analsys

Ketoconazole while Breastfeeding


CAS Number: 65277-42-1

A high protein-binding capacity may explain its low excretion into breastmilk observed after oral administration. 

Low levels that would reach the infant’s gut through breastmilk would barely be absorbed due to the alkaline environment that hinders the absorption.

 Because it is topically used on creams or vaginal ovules, it would have a low or nil absorption in mother’s plasma (Ene 1984, AEMPS 2015), hence, the amount excreted in milk is expected to be even lower than that following a systemic administration. 

It would be wise to avoid applying creams, gels and other topical products containing paraffin (mineral oil) on the nipple so that the infant could not ingest it (Noti 2003, Concin 2008). 

American Academy of Pediatrics: medication usually compatible with breastfeeding.

Ketoconazole Cream Breastfeeding Analsys - 2

Ketoconazole while Breastfeeding

CAS Number: 65277-42-1

Is Ketoconazole Cream safe while breastfeeding

Because there is little published experience with ketoconazole during breastfeeding and its potential liver enzyme inhibition and liver toxicity, other agents may be preferred. However, if oral ketoconazole is required by the mother, it may not be a reason to discontinue breastfeeding.[1] Taking the dose just before the infant's longest sleep period or avoiding breastfeeding from 2 to 5 hours after the dose might decrease the infant's exposure to ketoconazole. Use of ketoconazole shampoo or topical use on the skin by the mother poses little or no risk to the breastfed infant.[2][3] However, topical use on the breast or nipples should be avoided in nursing mothers because of possible oral ingestion by the infant and the availability of safer alternatives. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[4]

I am nursing mother and I have already used Ketoconazole Cream, what should I do?

It is always a good idea to keep your healthcare provider or doctor informed about your drug usage during pregnancy and breastfeeding but if you have not informed your doctor about Ketoconazole Cream and have used it then do not panic as Ketoconazole Cream is mostly safe in breastfeeding and should not cause any harm to your baby.

I am nursing mother and my doctor has suggested me to use Ketoconazole Cream, is it safe?

Usage of Ketoconazole Cream is safe for nursing mothers and baby, No worries.

If I am using Ketoconazole Cream, will my baby need extra monitoring?


Who can I talk to if I have questions about usage of Ketoconazole Cream in breastfeeding?

National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week