Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc while Breastfeeding
Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc is safe in breast-feeding or not.

What is Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc ?


Lisinopril and Hydrochlorothiazide Tablets, USP are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including lisinopril and hydrochlorothiazide. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in Black patients, and many antihypertensive drugs have additional approved indications and effects (e.g. on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy. These fixed-dose combinations are not indicated for initial therapy (see DOSAGE AND ADMINISTRATION). In using Lisinopril and Hydrochlorothiazide Tablets, USP, consideration should be given to the fact that an angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that lisinopril does not have a similar risk (see WARNINGS). In considering the use of Lisinopril and Hydrochlorothiazide Tablets, USP, it should be noted that ACE inhibitors have been associated with a higher rate of angioedema in Black than in non-Black patients (See WARNINGS, Lisinopril).

Is using Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc safe or dangerous while breastfeeding?

Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc low risk for breastfeeding
Hydrochlorothiazide and Lisinopril are the two main ingredients of Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc. Based on our individual analysis of Hydrochlorothiazide and Lisinopril we can safely say that Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc has low risk while breastfeeding. Below we have summarized the usage of Hydrochlorothiazide and Lisinopril while breastfeeding, we recommend you to go through it for better understanding of your usage.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers It is not known whether lisinopril is excreted in human milk. However, milk of lactating rats contains radioactivity following administration of 14C lisinopril. In another study, lisinopril was present in rat milk at levels similar to plasma levels in the dams. Thiazides do appear in human milk. Because of the potential for serious adverse reactions in nursing infants from ACE inhibitors and hydrochlorothiazide, a decision should be made whether to discontinue nursing and/or discontinue Lisinopril and Hydrochlorothiazide Tablets, taking into account the importance of the drug to the mother.

Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc Breastfeeding Analsys


Hydrochlorothiazide while Breastfeeding

Safe

CAS Number: 58-93-5

Thiazide diuretic drug. Excretion into breast milk is clinically non-significant. No side-effects were observed in a one-month old breastfed baby whose mother was treated with this medication. Drug level in the plasma of this child was undetectable. Long-term treatment with diuretic drugs (particularly Thiazide type ones with long-lasting effect and loop-acting mechanism) may inhibit lactation, mostly if lactation is not well-established yet. Use as lower dose as possible, especially during the first postnatal month. American Academy of Pediatrics 2013: Maternal Medication Usually Compatible With Breastfeeding. WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Lisinopril while Breastfeeding

Low Risk

CAS Number: 76547-98-3

Higher caution on early neonatal period is required. Check-up for blood hypotension and muscular hypotonia.


Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc Breastfeeding Analsys - 2


Hydrochlorothiazide while Breastfeeding

CAS Number: 58-93-5

Hydrochlorothiazide doses of 50 mg daily or less are acceptable during lactation. Intense diuresis with large doses may decrease breastmilk production.

Lisinopril while Breastfeeding

CAS Number: 83915-83-7

Because no information is available on the use of lisinopril during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.



I am nursing mother and I have already used Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc, what should I do?

Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc so you should inform him based on your convenience.


My doctor has prescribed me Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc, what should I do?

Though Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.


If I am using Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc, will my baby need extra monitoring?

Not much monitoring required while using Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc


Who can I talk to if I have questions about usage of Lisinopril With Hydrochlorothiazide | Aphena Pharma Solutions - Tennessee, Llc in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week