Quetiapine Fumarate Tablet while Breastfeeding
For most of the drugs advantages of taking medications overweighs the potential risks however some drugs could be really dangerous for breastfed baby hence every medication shall be considered separately. In this page we will discuss about purpose of Quetiapine Fumarate Tablet and its risk associated with lactation. We will also discuss the usage of Quetiapine Fumarate Tablet and some common side effects associated with Quetiapine Fumarate Tablet.

What is Quetiapine Fumarate Tablet used for?


Quetiapine tablets, USP are an atypical antipsychotic indicated for the treatment of: 1.Schizophrenia (1.1) 2.Bipolar I disorder manic episodes (1.2) 3.Bipolar disorder, depressive episodes (1.2) 1.1 Schizophrenia Quetiapine tablets, USP are indicated for the treatment of schizophrenia. The efficacy of quetiapine fumarate tablets in schizophrenia was established in three 6-week trials in adults and one 6-week trial in adolescents (13 to 17 years). The effectiveness of quetiapine fumarate tablets for the maintenance treatment of schizophrenia has not been systematically evaluated in controlled clinical trials [see Clinical Studies (14.1)]. 1.2 Bipolar Disorder Quetiapine tablets, USP are indicated for the acute treatment of manic episodes associated with bipolar I disorder, both as monotherapy and as an adjunct to lithium or divalproex. Efficacy was established in two 12-week monotherapy trials in adults, in one 3-week adjunctive trial in adults, and in one 3-week monotherapy trial in pediatric patients (10 to 17 years) [see Clinical Studies (14.2)]. Quetiapine tablets, USP are indicated as monotherapy for the acute treatment of depressive episodes associated with bipolar disorder. Efficacy was established in two 8-week monotherapy trials in adult patients with bipolar I and bipolar II disorder [see Clinical Studies (14.2)]. Quetiapine tablets, USP are indicated for the maintenance treatment of bipolar I disorder, as an adjunct to lithium or divalproex. Efficacy was established in two maintenance trials in adults. The effectiveness of quetiapine fumarate tablets as monotherapy for the maintenance treatment of bipolar disorder has not been systematically evaluated in controlled clinical trials [see Clinical Studies (14.2)]. 1.3 Special Considerations in Treating Pediatric Schizophrenia and Bipolar I Disorder Pediatric schizophrenia and bipolar I disorder are serious mental disorders, however, diagnosis can be challenging. For pediatric schizophrenia, symptom profiles can be variable, and for bipolar I disorder, patients may have variable patterns of periodicity of manic or mixed symptoms. It is recommended that medication therapy for pediatric schizophrenia and bipolar I disorder be initiated only after a thorough diagnostic evaluation has been performed and careful consideration given to the risks associated with medication treatment. Medication treatment for both pediatric schizophrenia and bipolar I disorder is indicated as part of a total treatment program that often includes psychological, educational and social interventions.

I am breastfeeding mother and I am using Quetiapine Fumarate Tablet. Can it have any bad effect on my kid? Shall I search for better alternative?

Quetiapine Fumarate Tablet safe for breastfeeding
Active ingredient in Quetiapine Fumarate Tablet is Quetiapine and based on our analysis of Quetiapine it appears that using Quetiapine Fumarate Tablet is safe in breastfeeding. Below is analysis of Quetiapine while breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Quetiapine was excreted into human milk. Because of the potential for serious adverse reactions in nursing infants from quetiapine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother’s health. In published case reports, the level of quetiapine in breast milk ranged from undetectable to 170 mcg/L. The estimated infant dose ranged from 0.09% to 0.43% of the weight-adjusted maternal dose. Based on a limited number (N=8) of mother/infant pairs, calculated infant daily doses range from less than 0.01 mg/kg (at a maternal daily dose up to 100 mg quetiapine) to 0.1 mg/kg (at a maternal daily dose of 400 mg).

Quetiapine Fumarate Tablet Breastfeeding Analsys


Quetiapine while Breastfeeding

Safe

CAS Number: 111974-72-2

It is excreted into breast milk in clinically significant amount. Clinical or development problems in infants whose mothers were treated have not been observed, whether at the short or long term.Very low plasma-levels in these infants were found. Galactorrhea may occur with or without an increased of Prolactin.


Quetiapine Fumarate Tablet Breastfeeding Analsys - 2


Quetiapine while Breastfeeding

CAS Number: 111974-69-7

Maternal quetiapine doses of up to 400 mg daily produce low levels in milk. Limited long-term follow-up of infants exposed to quetiapine indicates that infants generally developed normally. Systematic reviews of second-generation antipsychotics concluded that quetiapine seemed to be the first- or second-choice agent during breastfeeding.[1][2] Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.


Quetiapine Fumarate Tablet and breastfeeding

What should I do if I am breastfeeding mother and I am already exposed to Quetiapine Fumarate Tablet?

As usage of Quetiapine Fumarate Tablet is mostly safe while breastfeeding hence there should not be any concern. In case of any change in behavior or health of your baby you should inform your health care provider about usage of Quetiapine Fumarate Tablet else no further action is required.


I am nursing mother and my doctor has suggested me to use Quetiapine Fumarate Tablet, is it safe?

Definitely, Quetiapine Fumarate Tablet is safe in lactation for baby. No wonder your doctor has recommended it.


If I am using Quetiapine Fumarate Tablet, will my baby need extra monitoring?

No extra baby monitoring required while mother is using Quetiapine Fumarate Tablet


Who can I talk to if I have questions about usage of Quetiapine Fumarate Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week