Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release Breastfeeding

Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release is safe in breast-feeding or not.

What is Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release ?


Doxylamine succinate and pyridoxine hydrochloride delayed-release tablets are indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. Limitations of Use Doxylamine succinate and pyridoxine hydrochloride delayed-release tablets have not been studied in women with hyperemesis gravidarum. Doxylamine succinate and pyridoxine hydrochloride delayed-release tablets is a fixed dose combination drug product of doxylamine succinate, an antihistamine, and pyridoxine hydrochloride, a Vitamin B6 analog, indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. (1)

Is using Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release safe or dangerous while breastfeeding?

Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release high risk while breastfeeding
Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release consists two active ingredients Doxylamine succinate and Pyridoxine hydrochloride and as per our analysis of both we have determined the Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release is unsafe during breastfeeding. We recommend you to check both ingredients below for better understanding of Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Lactation Women should not breastfeed while using doxylamine succinate and pyridoxine hydrochloride delayed-release tablets. The molecular weight of doxylamine succinate is low enough that passage into breast milk can be expected. Excitement, irritability and sedation have been reported in nursing infants presumably exposed to doxylamine succinate through breast milk. Infants with apnea or other respiratory syndromes may be particularly vulnerable to the sedative effects of doxylamine succinate and pyridoxine hydrochloride delayed-release tablets resulting in worsening of their apnea or respiratory conditions. Pyridoxine hydrochloride is excreted into breast milk. There have been no reports of adverse events in infants presumably exposed to pyridoxine hydrochloride through breast milk.

Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release Breastfeeding Analsys


Doxylamine succinate while Breastfeeding

Unsafe

CAS Number: 469-21-6

It is a first generation antihistamine drug which is related to ethanolamine, with sedative and anti-muscarinic effects. It has been used as hypnotic and for vomiting relief. At latest update, relevant published data on excretion into breast milk were not found. Pharmacokinetic characteristics would favour that it may be excreted into breast milk in significant amount. On a telephone survey, 10% of infants whose mothers were on several types of antihistamine medication have suffered of colicky pain and irritability that disappeared without treatment. For both treatment of mothers and infants would be safer the use of tested antihistamine medication without sedative effect, especially in prematures and infants younger than 1 month of age. Whenever used while breastfeeding, the use of the lower effective dose and for the shortest time as possible is recommended. Follow-up for somnolence and feeding troubles should be warranted. Bed-sharing is not recommended when the mother is on this medication.

Pyridoxine hydrochloride while Breastfeeding

Safe

CAS Number: 58-56-0

Concentration of vitamin B6 in the breast milk is directly related to the amount present in diet with the possibility of a high increment by an excessive consumption through the diet. Daily allowance of vitamin B6 ranges from 2 to 3 mg. A balanced and varied diet is enough without a need for extra supplementation with this vitamin. Vitamin B6 deficiency is extremely rare since it is widely distributed in many foods. In those cases where supplementation is required, it is recommended not to exceed 40 mg a-day. There are controversial data on the capacity of a high dose of Pyridoxine to inhibit the secretion of Prolactin and suppress the milk production. The American Academy of Pediatrics rates it as usually compatible with breastfeeding.


Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release Breastfeeding Analsys - 2


Doxylamine succinate while Breastfeeding

CAS Number: 469-21-6

Small occasional doses of doxylamine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.



I am nursing mother and I have already used Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release, what should I do?

We have already established that Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release is unsafe in breastfeeding and breastfeeding while using Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release is not a good idea however if have already used and then breastfed the baby then you shall monitor the behavior and health of baby closely and inform your doctor as soon as possible. In case of emergency please call 911.


My doctor has prescribed me Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release, what should I do?

If your doctor knows that you are breastfeeding mother and still prescribes Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release then there must be good reason for that as Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release is considered unsafe, It usually happens when doctor finds that overall advantage of taking outweighs the overall risk.


If I am using Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release, will my baby need extra monitoring?

Yes, Extra monitoring is required if mother is using Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release and breastfeeding as it is considered unsafe for baby.


Who can I talk to if I have questions about usage of Doxylamine Succinate And Pyridoxine Hydrochloride Tablet, Delayed Release in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week