Glimepiride  Breastfeeding

Do you know that important immune protective proteins are present in breast milk? Breast milk also contains required vitamins, minerals, saturated and un saturated fats. These things are extremely important for development of healthy brain. If you are taking any medicine for short term or for the chronic reason then that passes in breast milk as well, that is why you should always check the drug with your health care provider. Here at DrLact we try to analyze drugs based on available researches and in this sheet we will present our analysis for Glimepiride .

What is Glimepiride used for?

Glimepiride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [see Clinical Studies ( 14.1)]. Limitations of Use Glimepiride tablets should not be used for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis, as it would not be effective in these settings. Glimepiride is a sulfonylurea indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus ( 1) Limitations of Use: Not for treating type 1 diabetes mellitus or diabetic ketoacidosis ( 1)

Is Glimepiride usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Glimepiride  high risk while breastfeeding
As Glimepiride is made of only Glimepiride, and Glimepiride is unsafe to use in breastfeeding we can safely reach on conclusion that Glimepiride is also unsafe to use while breastfeeding. Below is detailed analysis of Glimepiride and Glimepiride during location. We recommend you to go through provided detailed analysis as below take decision accordingly. We also recommend you talk to your health care provider before making final decision.

Statement of Manufacturer/Labeler about breastfeeding usage
8.2 Lactation Risk Summary Breastfed infants of lactating women using glimepiride should be monitored for symptoms of hypoglycemia (see Clinical Considerations). It is not known whether glimepiride is excreted in human milk and there are no data on the effects of glimepiride on milk production. Glimepiride is present in rat milk [see Data]. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for glimepiride and any potential adverse effects on the breastfed child from glimepiride or from the underlying maternal condition. Clinical Considerations Monitoring for adverse reactions Monitor breastfed infants for signs of hypoglycemia (e.g., jitters, cyanosis, apnea, hypothermia, excessive sleepiness, poor feeding, seizures). Data During prenatal and postnatal studies in rats, significant concentrations of glimepiride were present in breast milk and the serum of the pups. Offspring of rats exposed to high levels of glimepiride during pregnancy and lactation developed skeletal deformities consisting of shortening, thickening, and bending of the humerus during the postnatal period. These skeletal deformations were determined to be the result of nursing from mothers exposed to glimepiride.

Glimepiride Breastfeeding Analsys

Glimepiride while Breastfeeding


CAS Number: 93479-97-1

Sulfonilurea drugs stimulate secretion of endogen insulin. Oral anti-diabetic drugs are useless for treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower glucemia level. See section on Maternal diabetes mellitus

Glimepiride Breastfeeding Analsys - 2

Glimepiride while Breastfeeding

CAS Number: 93479-97-1

Because no information is available on the use of glimepiride during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with glimepiride.[1][2]

I already used Glimepiride and meanwhile I breastfed my baby should I be concerned?

We have already established that Glimepiride is unsafe in breastfeeding and breastfeeding while using Glimepiride is not a good idea however if have already used and then breastfed the baby then you shall monitor the behavior and health of baby closely and inform your doctor as soon as possible. In case of emergency please call 911.

I am nursing mother and my doctor has suggested me to use Glimepiride , is it safe?

If your doctor knows that you are breastfeeding mother and still prescribes Glimepiride then there must be good reason for that as Glimepiride is considered unsafe, It usually happens when doctor finds that overall advantage of taking outweighs the overall risk.

If I am using Glimepiride , will my baby need extra monitoring?

Yes, Extra monitoring is required if mother is using Glimepiride and breastfeeding as it is considered unsafe for baby.

Who can I talk to if I have questions about usage of Glimepiride in breastfeeding?

National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week