Carbidopa, Levodopa, And Entacapone Tablet Breastfeeding
Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Carbidopa, Levodopa, And Entacapone Tablet is safe in breast-feeding or not.

What is Carbidopa, Levodopa, And Entacapone Tablet used for?


Carbidopa, levodopa and entacapone tablets, a combination drug consisting of levodopa, carbidopa (dopa decarboxylase inhibitor), and entacapone (catechol-O-methyltransferase-COMT inhibitor) is indicated for the treatment of Parkinson's disease. Carbidopa, levodopa and entacapone tablets can be used: •To substitute (with equivalent strengths of each of the three components) carbidopa/levodopa and entacapone previously administered as individual products. •To replace carbidopa/levodopa therapy (without entacapone) when patients experience the signs and symptoms of end-of-dose “wearing-off” and when they have been taking a total daily dose of levodopa of 600 mg or less and have not been experiencing dyskinesias. Carbidopa, levodopa and entacapone tablets, a combination drug consisting of levodopa (aromatic amino acid), carbidopa (aromatic amino acid decarboxylation inhibitor), and entacapone (catechol-O-methyltransferase (COMT) inhibitor) is indicated for the treatment of Parkinson's disease. Carbidopa, levodopa and entacapone tablets are to be used: •To substitute (with equivalent strengths of each of the three components) for carbidopa/levodopa and entacapone previously administered as individual products (1) •To replace carbidopa/levodopa therapy (without entacapone) when patients experience the signs and symptoms of end-of-dose “wearing-off” and when they have been taking a total daily dose of levodopa of 600 mg or less and have not been experiencing dyskinesias (1)

I am currently breastfeeding and I want to know if using Carbidopa, Levodopa, And Entacapone Tablet is safe for my kid? Does it have any effect on milk production?

Carbidopa, Levodopa, And Entacapone Tablet Contains 3 active ingredients that are Carbidopa anhydrous, Levodopa, Entacapone. We do have breastfeeding analysis and safety rating of some of the active ingredients but unfortunately we do not have any information of some of active ingredients used. Below we have provided whatever information we do have. But please do not take any decision based on below provided information and contact your health care provider as this information is incomplete.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Carbidopa and entacapone are excreted in rat milk. It is not known whether entacapone, carbidopa, or levodopa is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when carbidopa, levodopa and entacapone tablets are administered to a nursing woman.

Carbidopa, Levodopa, And Entacapone Tablet Breastfeeding Analsys


Carbidopa anhydrous while Breastfeeding

Low Risk

CAS Number: 28860-95-9

When associated to levodopa it may decrease breast milk production.

Levodopa while Breastfeeding

Unsafe

CAS Number: 59-92-7

It may decrease breast milk production by inhibiting release of prolactin.

Carbidopa, Levodopa, And Entacapone Tablet Breastfeeding Analsys - 2


Levodopa while Breastfeeding

CAS Number: 59-92-7

Limited data indicate that levodopa is poorly excreted into breastmilk and that the sustained-release product may result in a smaller amount of drug transferred to the breastfed infant than with the immediate-release product. Several studies indicate that levodopa can decrease serum prolactin during lactation. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. The effect of long-term use of levodopa on breastfeeding has not been adequately evaluated, although one mother was able to successfully breastfeed her infant without apparent harm while using relatively low doses of levodopa and carbidopa for Parkinson's disease.

Carbidopa, Levodopa, And Entacapone Tablet and breastfeeding

I am nursing mother and I have already used Carbidopa, Levodopa, And Entacapone Tablet, what should I do?

Not much study has been done on safety of Carbidopa, Levodopa, And Entacapone Tablet in breastfeeding and its ingredients. Even we do not have complete information about usage of Carbidopa, Levodopa, And Entacapone Tablet in breastfeeding so at this point a trained medical professional could be your best bet. If you observe anything abnormal with your baby please contact 911.


My health care provider has asked me to use Carbidopa, Levodopa, And Entacapone Tablet, what to do?

If your doctor considers Carbidopa, Levodopa, And Entacapone Tablet safe enough to prescribe for you that means its benefits should outweigh its known risks for you.


If I am using Carbidopa, Levodopa, And Entacapone Tablet, will my baby need extra monitoring?

We are not Sure, Please check with your healthcare provider or doctor.


Who can I talk to if I have questions about usage of Carbidopa, Levodopa, And Entacapone Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week