Breast milk is superior in nutrition, It provides resistance against infections and allergies, It is naturally sterile. Despite all the advantages of breastfeeding some mothers choose to pause the breastfeeding in fear of harmful effects of medicines passing in breast milk. Are you wondering about breastfeeding and using Capecitabine 500 Mg ? Know what is Capecitabine 500 Mg and how it can affect your breast milk and whether Capecitabine 500 Mg is safe for your kid or not.
What is Capecitabine 500 Mg used for?
Capecitabine tablets are a nucleoside metabolic inhibitor with antineoplastic activity indicated for: Adjuvant Colon Cancer (1.1) Patients with Dukes’ C colon cancer Metastatic Colorectal Cancer (1.1) First-line as monotherapy when treatment with fluoropyrimidine therapy alone is preferred Metastatic Breast Cancer (1.2) In combination with docetaxel after failure of prior anthracycline-containing therapy As monotherapy in patients resistant to both paclitaxel and an anthracycline-containing regimen 1.1 Colorectal Cancer Capecitabine tablets are indicated as a single agent for adjuvant treatment in patients with Dukes’ C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred. Capecitabine tablets were non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS). Physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing single-agent capecitabine tablets in the adjuvant treatment of Dukes’ C colon cancer. Capecitabine tablets are indicated as first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred. Combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone. A survival benefit over 5-FU/LV has not been demonstrated with capecitabine tablets monotherapy. Use of capecitabine tablets instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage. 1.2 Breast Cancer Capecitabine tablets in combination with docetaxel are indicated for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy. Capecitabine tablets monotherapy is also indicated for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m 2 of doxorubicin or doxorubicin equivalents). Resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen.
Is Capecitabine 500 Mg usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?
Our analysis of Capecitabine which are active ingredients in Capecitabine 500 Mg indicates that Capecitabine 500 Mg is dangerous to use in breastfeeding. We strongly recommend you to go through detailed analysis of Capecitabine as below and do not use Capecitabine 500 Mg during breastfeeding.
Capecitabine 500 Mg Breastfeeding Analsys
Capecitabine while Breastfeeding Dangerous
CAS Number: 154361-50-9
Drug is cleared from the body in 25 elimination half-lives. Resuming breastfeeding is possible after 24 hours of pumping-and-dumping.
Capecitabine 500 Mg Breastfeeding Analsys - 2
Capecitabine while Breastfeeding
CAS Number: 154361-50-9
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence; the manufacturer recommends an abstinence period of 2 weeks. Capecitabine is metabolized to fluorouracil. Limited information indicates that a maternal continuous intravenous fluorouracil infusion at a dose of 200 mg/square meter daily produces undetectable levels in milk. If capecitabine use is undertaken, monitoring of the infant's complete blood count and differential is advisable. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk. Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.
What if I already have used Capecitabine 500 Mg?
You should immediately inform your health care provider about Capecitabine 500 Mg usage and your breastfeeding interval after usage of . If you feel baby is having abnormal behavior or any other health issue please call 911 immediately or contact nearest medical emergency center.
I am nursing mother and my doctor has suggested me to use Capecitabine 500 Mg, is it safe?
Please double check with your doctor if he is aware of your breastfeeding stratus, Ask your doctor if there is any safe alternative of Capecitabine 500 Mg. Check with your doctor if you shall temporally stop breastfeeding. You may go for second opinion as well. Still after all of this if your doctor still recommends Capecitabine 500 Mg then go for it as they have access on more detailed medical and scientific information and they understand your individual medical situation much better.
If I am using Capecitabine 500 Mg, will my baby need extra monitoring?
Extreme level of monitoring required as Capecitabine 500 Mg could be dangerous for kid.
Who can I talk to if I have questions about usage of Capecitabine 500 Mg in breastfeeding?
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week