Zonisamide 100 In 1 Bottle Breastfeeding
There are high number of clear evidence that breastfeeding provides best nutrition that you can give to your baby. It is also evident that lactation is good for mothers health as well. Evolution has designed breastfeeding in a way that it caters all nutritional need of your child. However modern medicine is quite new for evolution, that is why mothers body is not well prepared to filter unnecessary chemical found in medicines. It becomes a necessity to figure out which drug is safe and which drug is dangerous for your newborn while nursing. In this article we will understand function of Zonisamide 100 In 1 Bottle and its suitability with breastfeeding.

What is Zonisamide 100 In 1 Bottle used for?

Zonisamide capsules USP are indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.

I am breastfeeding mother and I am using Zonisamide 100 In 1 Bottle. Can it have any bad effect on my kid? Shall I search for better alternative?

Zonisamide 100 In 1 Bottle low risk for breastfeeding
Zonisamide is the one and only active ingredient present in Zonisamide 100 In 1 Bottle. Zonisamide in itself is a low risk drug for lactation so it is easy to understand that Zonisamide 100 In 1 Bottle also comes in category of Low Risk item while breastfeeding. Below is the summary of Zonisamide in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
Use in Nursing Mothers Zonisamide is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from zonisamide, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account the importance of the drug to the mother.

Zonisamide 100 In 1 Bottle Breastfeeding Analsys

Zonisamide while Breastfeeding

Low Risk

CAS Number: 68291-97-4

Zonisamide is excreted in breast milk in amounts that could be clinically significant, since the infant receives a relative dose well above 10% (Pack 2006, Crawford 2005, Tomson 2005, Shimoyama 1999, Kimura 1998). In spite of this high excretion in breast milk, infants who were breastfed by mothers taking zonisamide had no clinical problems (Shimoyama 1999) and their plasma zonisamide levels were only 15 to 17% of those measured in the mother (Kawada 2002, abstracts-P55 2011). Due to poor pharmacokinetics for breastfeeding with low protein binding and slow drug elimination (Jacob 2016) and the limited existing literature in relation to breastfeeding (Reimers 2014), it may be advisable to choose antiepileptics whose safety is better known (Hutchinson 2013, Davanzo 2013). If it is administered during breastfeeding, use the minimum effective dose (Reimers 2014) and monitor the infant's appetite, weight curve, psychomotor development, irritability, diarrhea, dehydration or acidosis, and it may be desirable to measure monthly plasma levels in the infant (Davanzo 2013, Pennell 2003). Some authors propose partial breastfeeding to decrease the dose that the infant receives through breast milk (Ando 2014).

Zonisamide 100 In 1 Bottle Breastfeeding Analsys - 2

Zonisamide while Breastfeeding

CAS Number: 68291-97-4

Limited information indicates that maternal doses of zonisamide up to 400 mg daily produce high levels in milk and infant serum, but serum levels in neonates decrease during the first month of life while nursing. Although no adverse reactions have been reported in breastfed infants, the number of infants reported have been small. Alternative drugs are preferred, but if it must be given, monitor the infant for drowsiness, adequate weight gain, and developmental milestones, especially in younger or exclusively breastfed infants and when using combinations of anticonvulsant drugs. Some clinicians recommend that mothers taking zonisamide only partially breastfeed in order to reduce the exposure of the infant to the drug and to consider monitoring infants' serum zonisamide concentrations.[1]

What should I do if I am breastfeeding mother and I am already exposed to Zonisamide 100 In 1 Bottle?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Zonisamide 100 In 1 Bottle then you shall inform your doctor, But you should not be worried too much as Zonisamide 100 In 1 Bottle comes in category of low risk drug.

I am nursing mother and my doctor has suggested me to use Zonisamide 100 In 1 Bottle, is it safe?

Zonisamide 100 In 1 Bottle comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.

If I am using Zonisamide 100 In 1 Bottle, will my baby need extra monitoring?

Not much

Who can I talk to if I have questions about usage of Zonisamide 100 In 1 Bottle in breastfeeding?

National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week