CAS Number: 469-21-6
It is a first generation antihistamine drug which is related to ethanolamine, with sedative and anti-muscarinic effects. It has been used as hypnotic and for vomiting relief. At latest update, relevant published data on excretion into breast milk were not found. Pharmacokinetic characteristics would favour that it may be excreted into breast milk in significant amount. On a telephone survey, 10% of infants whose mothers were on several types of antihistamine medication have suffered of colicky pain and irritability that disappeared without treatment. For both treatment of mothers and infants would be safer the use of tested antihistamine medication without sedative effect, especially in prematures and infants younger than 1 month of age. Whenever used while breastfeeding, the use of the lower effective dose and for the shortest time as possible is recommended. Follow-up for somnolence and feeding troubles should be warranted. Bed-sharing is not recommended when the mother is on this medication.
CAS Number: 469-21-6
Small occasional doses of doxylamine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.
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