It is a well known fact that breastfeeding is best source of nutrition for infants. Breast milk provides minerals, vitamins and antibodies in most acceptable format when they need it. Nutrition taken by mother passes to breast-milk and same thing applies to medicines taken by mothers. Not all drugs cause problem for baby but some do. Lets analyze if Pregabalin Pregabalin 100 Mg is safe for baby while breastfed.
What is Pregabalin Pregabalin 100 Mg used for?
Pregabalin capsule is indicated for: • Management of neuropathic pain associated with diabetic peripheral neuropathy • Management of postherpetic neuralgia • Adjunctive therapy for the treatment of partial-onset seizures in patients 17 years of age and older • Management of fibromyalgia • Management of neuropathic pain associated with spinal cord injury Pediatric use information is approved for Pfizer’s LYRICA (pregabalin) Capsules and Oral Solution products. However, due to Pfizer’s marketing exclusivity rights, this drug product is not labeled with that pediatric information. Pregabalin capsule is indicated for: • Neuropathic pain associated with diabetic peripheral neuropathy (DPN) (1) • Postherpetic neuralgia (PHN) (1) • Adjunctive therapy for the treatment of partial-onset seizures in patients 17 years of age and older (1) • Fibromyalgia (1) • Neuropathic pain associated with spinal cord injury (1)
I am breastfeeding mother and I am using Pregabalin Pregabalin 100 Mg. Can it have any bad effect on my kid? Shall I search for better alternative?
Pregabalin Pregabalin 100 Mg contains only one active ingredient that is Pregabalin. We have analyzed the usage of Pregabalin in breastfeeding and our analysis suggest that Pregabalin poses Low risk for infant while breastfeeding and hence Pregabalin Pregabalin 100 Mg itself shall be considered Low risk item for breastfeeding.
Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Females and Males of Reproductive Potential Infertility Male Effects on Spermatogenesis In a randomized, double-blind, placebo-controlled non-inferiority study to assess the effect of pregabalin on sperm characteristics, healthy male subjects received pregabalin at a daily dose up to 600 mg (n=111) or placebo (n=109) for 13 weeks (one complete sperm cycle) followed by a 13-week washout period (off-drug). A total of 65 subjects in the pregabalin group (59%) and 62 subjects in the placebo group (57%) were included in the per protocol (PP) population. These subjects took study drug for at least 8 weeks, had appropriate timing of semen collections and did not have any significant protocol violations. Among these subjects, approximately 9% of the pregabalin group (6/65) vs. 3% in the placebo group (2/62) had greater than or equal to 50% reduction in mean sperm concentrations from baseline at Week 26 (the primary endpoint). The difference between pregabalin and placebo was within the pre-specified non-inferiority margin of 20%. There were no adverse effects of pregabalin on sperm morphology, sperm motility, serum FSH or serum testosterone levels as compared to placebo. In subjects in the PP population with greater than or equal to 50% reduction in sperm concentration from baseline, sperm concentrations were no longer reduced by greater than or equal to 50% in any affected subject after an additional 3 months off-drug. In one subject, however, subsequent semen analyses demonstrated reductions from baseline of greater than or equal to 50% at 9 and 12 months off-drug. The clinical relevance of these data is unknown. In the animal fertility study with pregabalin in male rats, adverse reproductive and developmental effects were observed [see Nonclinical Toxicology (13.1)].
Pregabalin Pregabalin 100 Mg Breastfeeding Analsys
Pregabalin while Breastfeeding Low Risk
CAS Number: 148553-50-8
Anti-epileptic drug with structural properties similar to Gabapentin. Also used in the treatment of anxiety disorders, neuropathic pain and fibromyalgia. It is excreted into breast milk in small quantities as plasma levels in infants were less than 10% of maternal ones when compared to those of treated mothers. No side effects were observed in those infants. Because less experience has been published than with other drugs of the same group, alternatives that are known as safer should be considered of choice during the neonatal period or in case of preterm babies.
Pregabalin Pregabalin 100 Mg Breastfeeding Analsys - 2
Pregabalin while Breastfeeding
CAS Number: 148553-50-8
Very limited data indicate that amounts of pregabalin in breastmilk are low. If pregabalin is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
What should I do if already breastfed my kid after using Pregabalin Pregabalin 100 Mg?
During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Pregabalin Pregabalin 100 Mg then you shall inform your doctor, But you should not be worried too much as Pregabalin Pregabalin 100 Mg comes in category of low risk drug.
I am nursing mother and my doctor has suggested me to use Pregabalin Pregabalin 100 Mg, is it safe?
Though Pregabalin Pregabalin 100 Mg dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.
If I am using Pregabalin Pregabalin 100 Mg, will my baby need extra monitoring?
Who can I talk to if I have questions about usage of Pregabalin Pregabalin 100 Mg in breastfeeding?
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week