Azathioprine Tablet Breastfeeding

There are high number of clear evidence that breastfeeding provides best nutrition that you can give to your baby. It is also evident that lactation is good for mothers health as well. Evolution has designed breastfeeding in a way that it caters all nutritional need of your child. However modern medicine is quite new for evolution, that is why mothers body is not well prepared to filter unnecessary chemical found in medicines. It becomes a necessity to figure out which drug is safe and which drug is dangerous for your newborn while nursing. In this article we will understand function of Azathioprine Tablet and its suitability with breastfeeding.

What is Azathioprine Tablet used for?


Azathioprine tablets are indicated as an adjunct for the prevention of rejection in renal homotransplantation. It is also indicated for the management of active rheumatoid arthritis to reduce signs and symptoms. Renal Homotransplantation Azathioprine tablets are indicated as an adjunct for the prevention of rejection in renal homotransplantation. Experience with over 16,000 transplants shows a 5-year patient survival of 35% to 55%, but this is dependent on donor, match for HLA antigens, anti-donor or anti-B-cell alloantigen antibody, and other variables. The effect of azathioprine tablets on these variables has not been tested in controlled trials. Rheumatoid Arthritis Azathioprine tablets are indicated for the treatment of active rheumatoid arthritis (RA) to reduce signs and symptoms. Aspirin, non-steroidal anti-inflammatory drugs and/or low dose glucocorticoids may be continued during treatment with azathioprine tablets. The combined use of azathioprine tablets with disease modifying anti-rheumatic drugs (DMARDs) has not been studied for either added benefit or unexpected adverse effects. The use of azathioprine tablets with these agents cannot be recommended.

Is Azathioprine Tablet usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Azathioprine Tablet safe for breastfeeding
As per our analysis Azathioprine Tablet contains only one ingredient and that is Azathioprine. We have analyzed Azathioprine and it seems to be safe to use Azathioprine while breastfeeding, that means usage of Azathioprine Tablet shall be safe while breastfeeding. Below you can check more details of Azathioprine usage in breastfeeding. We recommend you to go through provided detailed analysis as below take decision accordingly.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers The use of azathioprine tablets in nursing mothers is not recommended. Azathioprine or its metabolites are transferred at low levels, both transplacentally and in breast milk.17, 18, 19 Because of the potential for tumorigenicity shown for azathioprine, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Azathioprine Tablet Breastfeeding Analsys


Azathioprine while Breastfeeding

Safe

CAS Number: 446-86-6

Even though it is metabolized to mercaptopurine, just tiny amounts of this drug have been found in breast milk (4 - 18 micrograms/liter). Among several breastfed infants of mothers who were treated with Azathioprine failed to be detected in the blood nor side effects were found. Long-term infectious diseases were not more common among exposed infants. Exposition would be minimized if nursing is resumed 3 hours after last dose.

Azathioprine Tablet Breastfeeding Analsys - 2


Azathioprine while Breastfeeding

CAS Number: 446-86-6

Most experts consider breastfeeding during azathioprine to be acceptable.[1][2][3][4][5][6][7][8] Studies in women with inflammatory bowel disease, systemic lupus erythematosus or transplantation taking doses of azathioprine up to 200 mg daily for immunosuppression have found either low or unmeasurable levels of the active metabolites in milk and infant serum. Some evidence indicates a lack of adverse effects on the health and development of infants exposed to azathioprine during breastfeeding up to 3.5 years of age, but long-term follow-up for effects such as carcinogenesis have not been performed. Mothers with decreased activity of the enzyme that detoxifies azathioprine metabolites may transmit higher levels of drug to their infants in breastmilk. Cases of mild, asymptomatic neutropenia have been reported, so it might be desirable to monitor exclusively breastfed infants with a complete blood count with differential, and liver function tests if azathioprine is used during lactation, although some authors feel that monitoring is unnecessary.[9] Avoiding breastfeeding for 4 hours after a dose should markedly decrease the dose received by the infant in breastmilk.[10]


What should I do if I am breastfeeding mother and I am already exposed to Azathioprine Tablet?

Azathioprine Tablet is safe in breastfeeding and should not create any health problem for your baby but in case you feel any health issue associated with Azathioprine Tablet you should contact your doctor or health care provider. Be it pregnancy or lactation you shall keep your doctor informed.


I am nursing mother and my doctor has suggested me to use Azathioprine Tablet, is it safe?

Usage of Azathioprine Tablet is safe for nursing mothers and baby, No worries.


If I am using Azathioprine Tablet, will my baby need extra monitoring?

No


Who can I talk to if I have questions about usage of Azathioprine Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

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