Zerit | Stavudine Capsule, Gelatin Coated while Breastfeeding
American Academy of Pediatrics and other medical experts exclusively recommend to breastfeed the baby for first 6 months. Once you introduce baby to other foods it is recommended to breastfeed for at least first year of babys life. Taking medication while breastfeeding could be tricky as most drugs pass in breast milk. In this article we will evaluate Zerit | Stavudine Capsule, Gelatin Coated for its safety in breastfeeding.

What is Zerit | Stavudine Capsule, Gelatin Coated used for?


ZERIT (stavudine), in combination with other antiretroviral agents, is indicated for the treatment of HIV-1 infection (see Clinical Studies). CLINICAL STUDIES Combination Therapy The combination use of ZERIT is based on the results of clinical studies in HIV-infected patients in double- and triple-combination regimens with other antiretroviral agents. One of these studies (START 1) was a multicenter, randomized, open-label study comparing ZERIT (40 mg twice daily) plus lamivudine plus indinavir to zidovudine plus lamivudine plus indinavir in 202 treatment-naive patients. Both regimens resulted in a similar magnitude of inhibition of HIV RNA levels and increases in CD4 cell counts through 48 weeks. Monotherapy The efficacy of ZERIT was demonstrated in a randomized, double-blind study (AI455-019, conducted 1992-1994) comparing ZERIT with zidovudine in 822 patients with a spectrum of HIV-related symptoms. The outcome in terms of progression of HIV disease and death was similar for both drugs.

What are the risk associated with Zerit | Stavudine Capsule, Gelatin Coated usage while breastfeeding? What precautions shall I take while using it in breastfeeding?

Zerit | Stavudine Capsule, Gelatin Coated contains Stavudine as active ingredients, . We do not have safety rating of Stavudine but we do have analysis of Stavudine, which is used in manufacturing of Zerit | Stavudine Capsule, Gelatin Coated. You can get a good idea about Zerit | Stavudine Capsule, Gelatin Coated usage while breastfeeding by going through our detailed analysis as below.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers The Centers for Disease Control and Prevention recommend that HIV-infected mothers not breast-feed their infants to avoid risking postnatal transmission of HIV. Studies in lactating rats demonstrated that stavudine is excreted in milk. Although it is not known whether stavudine is excreted in human milk, there exists the potential for adverse effects from stavudine in nursing infants. Because of both the potential for HIV transmission and the potential for serious adverse reactions in nursing infants, mothers should be instructed not to breast-feed if they are receiving ZERIT.

Zerit | Stavudine Capsule, Gelatin Coated Breastfeeding Analsys


Stavudine while Breastfeeding

CAS Number: 3056-17-5

In the United States and other developed countries, HIV-infected mothers should generally not breastfeed their infants. Published experience with stavudine during breastfeeding is limited. In countries in which no acceptable, feasible, sustainable and safe replacement feeding is available, World Health Organization guidelines recommend that all women with an HIV infection who are pregnant or breastfeeding should be maintained on antiretroviral therapy for at least the duration of risk for mother-to-child transmission. Mothers should exclusively breastfeed their infants for the first 6 months of life; breastfeeding with complementary feeding should continue through at least 12 months of life up to 24 months of life.[1] The first choice regimen for nursing mothers is tenofovir, efavirenz and either lamivudine or emtricitabine. If these drugs are unavailable, alternative regimens include: 1) zidovudine, lamivudine and efavirenz; 2) zidovudine, lamivudine and nevirapine; or 3) tenofovir, nevirapine and either lamivudine or emtricitabine. Exclusively breastfed infants should also receive 6 weeks of prophylaxis with nevirapine. Stavudine should not be used in first-line regimens because of its metabolic toxicities.[2][3]

Is Zerit | Stavudine Capsule, Gelatin Coated safe while breastfeeding

I already used Zerit | Stavudine Capsule, Gelatin Coated and meanwhile I breastfed my baby should I be concerned?

We are not completely sure about safety of Zerit | Stavudine Capsule, Gelatin Coated in breastfeeding. We would suggest you to contact your doctor or health care provider and explain your situation with Zerit | Stavudine Capsule, Gelatin Coated. If you observe anything abnormal with your baby please call 911 or contact emergency services in your area.


My health care provider has asked me to use Zerit | Stavudine Capsule, Gelatin Coated, what to do?

If your doctor considers Zerit | Stavudine Capsule, Gelatin Coated safe enough to prescribe for you that means its benefits outweigh its known risks.


If I am using Zerit | Stavudine Capsule, Gelatin Coated, will my baby need extra monitoring?

Not Sure, Please check with your doctor or lactation consultant.


Who can I talk to if I have questions about usage of Zerit | Stavudine Capsule, Gelatin Coated in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

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