CAS Number: 79559-97-0
Excreted in tiny amounts into breast milk. Serum levels of breastfed infants whose mothers are on Sertraline are usually undetectable or very low. No harm effect has been observed on health and short or long term development of infants. Transient troubles in the early neonatal period like drug withdrawal syndrome among newborn or premature infants with high serum levels as a result of treatment with Sertraline to the mother during pregnancy have been observed. Sertraline causes fewer problems related to galactorrhea than other antidepressant drugs. It is probably the safest antidepressant medication while breastfeeding. Mothers who are treated with antidepressant medicaction are in need of stronger support for a higher risk of early breastfeeding failure.
CAS Number: 79617-96-2
Because of the low levels of sertraline in breastmilk, amounts ingested by the infant are small and is usually not detected in the serum of the infant, although the weakly active metabolite norsertraline (desmethylsertraline) is often detectable in low levels in infant serum. Rarely, preterm infants with impaired metabolic activity might accumulate the drug and demonstrate symptoms similar to neonatal abstinence. Most authoritative reviewers consider sertraline a preferred antidepressants during breastfeeding. Mothers taking an SSRI during pregnancy and postpartum may have more difficulty breastfeeding, although this might be a reflection of their disease state. These mothers may need additional breastfeeding support. Breastfed infants exposed to an SSRI during the third trimester of pregnancy have a lower risk of poor neonatal adaptation than formula-fed infants.
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