Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Aprepitant Capsule is safe in breast-feeding or not.
What is Aprepitant Capsule used for?
Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist, indicated: •in combination with other antiemetic agents for prevention of : •acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin (1.1) •nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC) (1.1) •for prevention of postoperative nausea and vomiting (PONV) in adults (1.2) Limitations of Use (1.3) •Aprepitant capsules have not been studied for treatment of established nausea and vomiting. •Chronic continuous administration of aprepitant capsules are not recommended. 1.1 Prevention of Chemotherapy Induced Nausea and Vomiting (CINV) Aprepitant capsules, in combination with other antiemetic agents, are indicated for the prevention of: •acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin. •nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC). Pediatric use information is approved for Merck Sharp & Dohme Corp.’s EMEND® (aprepitant) capsules. However, due to Merck Sharp & Dohme Corp’s marketing exclusivity rights, this drug product is not labeled with that information. 1.2 Prevention of Postoperative Nausea and Vomiting (PONV) Aprepitant capsules are indicated in adults for the prevention of postoperative nausea and vomiting. 1.3 Limitations of Use •Aprepitant capsules have not been studied for the treatment of established nausea and vomiting. •Chronic continuous administration of aprepitant capsules is not recommended because it has not been studied, and because the drug interaction profile may change during chronic continuous use.
Is Aprepitant Capsule usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?
Aprepitant is the one and only active ingredient present in Aprepitant Capsule. Aprepitant in itself is a low risk drug for lactation so it is easy to understand that Aprepitant Capsule also comes in category of Low Risk item while breastfeeding. Below is the summary of Aprepitant in breastfeeding.
Aprepitant Capsule Breastfeeding Analsys
Aprepitant while Breastfeeding Low Risk
CAS Number: 170729-80-3
On latest update relevant data on breastfeeding was not found. Its moderately high molecular weight, and, especially a high plasma protein binding make excretion into breast milk unlikely Side effects are few and usually mild.
I am nursing mother and I have already used Aprepitant Capsule, what should I do?
During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Aprepitant Capsule then you shall inform your doctor, But you should not be worried too much as Aprepitant Capsule comes in category of low risk drug.
I am nursing mother and my doctor has suggested me to use Aprepitant Capsule, is it safe?
Though Aprepitant Capsule dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.
If I am using Aprepitant Capsule, will my baby need extra monitoring?
Who can I talk to if I have questions about usage of Aprepitant Capsule in breastfeeding?
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week