Intralipid | Soybean Oil 20 G In 100 Ml Breastfeeding
Do you know that important immune protective proteins are present in breast milk? Breast milk also contains required vitamins, minerals, saturated and un saturated fats. These things are extremely important for development of healthy brain. If you are taking any medicine for short term or for the chronic reason then that passes in breast milk as well, that is why you should always check the drug with your health care provider. Here at DrLact we try to analyze drugs based on available researches and in this sheet we will present our analysis for Intralipid | Soybean Oil 20 G In 100 Ml.

What is Intralipid | Soybean Oil 20 G In 100 Ml used for?


CLINICAL PARTICULARS Therapeutic indications Intralipid is indicated in patients needing intravenous nutrition to supply energy and essential fatty acids. Intralipid is also indicated in patients with essential fatty acid deficiency (EFAD) who cannot maintain or restore a normal essential fatty acid pattern by oral intake. Posology and method of administration The ability to eliminate Intralipid should govern the dosage and infusion rate. See below Fat elimination. Dosage Intralipid 10% 1g triglycerides corresponds to 10 ml Intralipid 10%. Adults. The recommended maximum dosage is 3 g triglycerides/kg body weight/day. Within this upper limit, Intralipid can be given to contribute up to 70% of the energy requirements, also in patients with highly increased energy requirements. The infusion rate for Intralipid 10% should not exceed 500 ml in 5 hours. Neonates and infants. The recommended dosage range in neonates and infants is 0.5-4 g triglycerides/ kg bw/day. The rate of infusion should not exceed 0.17 g triglycerides/kg bw/hour (4 g in 24 hours). In prematures and low birthweight neonates, Intralipid should preferably be infused continuously over 24 hours. The initial dosage should be 0.5-1 g/kg bw/day followed by a successive increase by 0.5-1 g/kg bw/day up to 2g/kg bw/day. Only with close monitoring of serum triglyceride concentration, liver tests and oxygen saturation may the dosage be increased to 4 g/kg bw/day. The rates given are maximum rates and no attempt should be made to exceed these in order to compensate for missed doses. Dosage Intralipid 20% 1g triglycerides corresponds to 5 ml Intralipid 20%. Adults. The recommended maximum dosage is 3 g triglycerides/ kg body weight/day. Within this upper limit, Intralipid can be given to contribute up to 70% of the energy requirements, also in patients with highly increased energy requirements. The infusion rate for Intralipid 20% should not exceed 500 ml in 5 hours. Neonates and infants. The recommended dosage range in neonates and infants is 0.5-4 g triglycerides/ kg bw/day. The rate of infusion should not exceed 0.17 g triglycerides/kg bw/hour (4 g in 24 hours). In prematures and low birthweight neonates, Intralipid should preferably be infused continuously over 24 hours. The initial dosage should be 0.5-1 g/kg bw/day followed by a successive increase by 0.5-1 g/kg bw/day up to 2g/kg bw/day. Only with close monitoring of serum triglyceride concentration, liver tests and oxygen saturation may the dosage be increased to 4 g/kg bw/day. The rates given are maximum rates and no attempt should be made to exceed these in order to compensate for missed doses. Essential fatty acid deficiency (EFAD). To prevent or correct essential fatty acid deficiency, 4 to 8% of the nonprotein energy should be supplied as Intralipid to provide sufficient amounts of linoleic and linolenic acid. When EFAD is associated with stress, the amount of Intralipid needed to correct the deficiency may be substantially increased. FAT ELIMINATION Adults. The ability to eliminate fat should be closely monitored in patients with conditions mentioned in section “Special warnings and special precautions for use”, and in patients given Intralipid for more than one week. This is done by collecting a blood sample after a fat-free clearance period of 5-6 hours. Blood cells are then separated from plasma by centrifugation. If the plasma is opalescent, the infusion should be postponed. The sensitivity of this method is such that hypertriglyceridaemia can pass undetected. Therefore, it is recommended that serum triglyceride concentrations should be measured in patients who are likely to have impaired fat tolerance. Neonates and infants. The ability to eliminate fat should be tested regularly in neonates and infants. Measuring serum triglyceride levels is the only reliable method. Contra-indications Intralipid is contraindicated in patients with acute shock and in patients with severe hyperlipemia. Severe liver insufficiency. Hemophagocytotic syndrome. Hypersensitivity to egg-, soya- or peanut protein or to any of the active substances or excipients. Special warnings and special precautions for use Intralipid should be given with caution in conditions of impaired lipid metabolism as in renal insufficiency, uncompensated diabetes mellitus, pancreatitis, impaired liver function, hypothyroidism (if hypertri-glyceridemic) and sepsis. If Intralipid is given to patients with these conditions, close monitoring of the serum triglyceride concentration is obligatory. This medicinal product contains soya-bean oil and egg phospholipids, which may rarely cause allergic reactions. Cross allergic reactions have been observed between soybean and peanut. Intralipid should be given with caution to neonates and prematures with hyperbilirubinemia and cases with suspected pulmonary hypertension. In neonates, particularly prematures on long term parenteral nutrition, platelet count, liver tests and serum triglyceride concentration should be monitored. Intralipid may interfere with certain laboratory measurements (bilirubin, lactate dehydrogenase, oxygen saturation, Hb etc) if blood is sampled before fat has been adequately cleared from the blood stream. Fat is cleared after a fat free interval of 5-6 hours in most patients. Interaction with other medicaments and other forms of interaction Some drugs, like insulin, may interfere with the body’s lipase system. This kind of interaction seems, however, to be of only limited clinical importance. Heparin in clinical doses causes a transient increase in lipolysis in plasma, resulting in a transient decrease in triglyceride clearance due to depletion of lipoprotein lipase. Soybean oil has a natural content of vitamin K1. This is considered important only for patients treated with coumarin derivatives, which interfere with vitamin K1. Pregnancy and lactation No adverse reactions connected with pregnancy and lactation have been reported. Effects on ability to drive and use machines No effects on the ability to drive and operate machines are to be expected. Undesirable effects Intralipid infusion may cause a rise in body temperature and, less frequently, shivering, chills and nausea/vomiting (incidence<1%). Reports of other adverse events in conjunction with Intralipid infusion are extremely rare, less than one adverse event per one million infusions. System Organ Class Frequency Symptom according to WHO Body as a whole Uncommon Headache general disorders (>1/1000, <1/100) Rise in body temperature, shivering, chills, tiredness Very rare Anaphylactic (<1/10 000) reaction Cardiovascular disorders Very rare Circulatory effects (<1/10 000) (e.g. hyper/hypotension) Gastrointestinal disorders Uncommon Abnormal pain (>1/1000, <1/100) Nausea, vomiting Liver & biliary system Very rare Transient increase disorders (<1/10 000) in liver function test Musculoskeletal, Very rare Abdominal pain connective tissue and (<1/10 000) bone disorders Platelet, bleeding & Very rare Thrombocytopenia clotting disorders (<1/10 000) Red blood cell disorders Very rare Haemolysis, (<1/10 000) reticulocytosis Reproductive disorders, Very rare Priapism male (<1/10 000) Skin and appendages Very rare Rash, urticaria disorders (<1/10 000) Trombocytopenia has been reported in association with prolonged treatment with Intralipid in infants. Transient increase in liver function tests after prolonged intravenous nutrition with or without Intralipid have also been noted. Increased cholesterol has been observed with infants after long term treatment with Intralipid 10%. The reasons are not clear at present. Fat overload syndrome. An impaired capacity to eliminate Intralipid may lead to the fat overload syndrome as a result of overdosage. However, this syndrome may appear also at recommended rates of infusion in association with a sudden change in the patient’s clinical condition, such as renal function impairment or infection. The fat overload syndrome is characterised by hyperlipemia, fever, fat infiltration and disorders in various organs and coma. All symptoms are usually reversible if the infusion of Intralipid is discontinued. Overdose See Undesirable effects, “Fat overload syndrome”. Severe overdose of fat emulsions containing triglycerides can, especially if carbohydrates are not administered simultaneously, lead to acidosis.

What are the risk associated with Intralipid | Soybean Oil 20 G In 100 Ml usage while breastfeeding? What precautions shall I take while using it in breastfeeding?

Intralipid | Soybean Oil 20 G In 100 Ml low risk for breastfeeding
Intralipid | Soybean Oil 20 G In 100 Ml contains only one active ingredient that is Soybean oil. We have analyzed the usage of Soybean oil in breastfeeding and our analysis suggest that Soybean oil poses Low risk for infant while breastfeeding and hence Intralipid | Soybean Oil 20 G In 100 Ml itself shall be considered Low risk item for breastfeeding.

Intralipid | Soybean Oil 20 G In 100 Ml Breastfeeding Analsys


Soybean oil while Breastfeeding

Low Risk

CAS Number: 8001-22-7

Seeds, oil and extracts of this plant contain Lecithin and Isoflavones like Genistein, Glycitein and Daidzein. Lecithin is formed by phospholipids with hypolipidemic properties (see particular information on LECITHIN). Isoflavones are phytoestrogens which is a property that is being used for treatment of hyperlipidemias and disorders related to menopause. Ingestion of soy derived products by nursing mothers may be a cause of increase concentration in the mother’s plasma, breast milk and infant’s urine. Despite of that soy has been consumed from ancient times by Asian population and could offer some benefit for the welfare, it may act as hormonal disruptor on the endocrine system, especially is the product contains Bisphenol, hence, high exposition during infancy should be avoided. Therefore, it is not recommended an extensive consumption of it while breastfeeding since estrogens may decrease, at least theoretically, the milk production.


Intralipid | Soybean Oil 20 G In 100 Ml and breastfeeding

I already used Intralipid | Soybean Oil 20 G In 100 Ml and meanwhile I breastfed my baby should I be concerned?

Intralipid | Soybean Oil 20 G In 100 Ml is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Intralipid | Soybean Oil 20 G In 100 Ml so you should inform him based on your convenience.


I am nursing mother and my doctor has suggested me to use Intralipid | Soybean Oil 20 G In 100 Ml, is it safe?

Intralipid | Soybean Oil 20 G In 100 Ml comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.


If I am using Intralipid | Soybean Oil 20 G In 100 Ml, will my baby need extra monitoring?

Not much monitoring required while using Intralipid | Soybean Oil 20 G In 100 Ml


Who can I talk to if I have questions about usage of Intralipid | Soybean Oil 20 G In 100 Ml in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week