CAS Number: 57109-90-7
Long-acting benzodiazepine. Most of the clorazepate is metabolized to N-desmethyldiazepam (nordiazepam) which is the active metabolite of diazepam. It is excreted in breast milk in clinically insignificant amounts (Rey 1979). Sedation has been observed in infants whose mothers were taking diazepam (Wesson 1985). Due to the lack of publications on this subject, until more information is known about this drug in relation to breastfeeding, safer known alternatives are preferred, especially in the neonatal period and in case of prematurity (McElhatton 1994). Occasional and low-dose use of benzodiazepines is compatible with breastfeeding. It is advisable to choose short-duration benzodiazepines and to use the minimum effective dose. Monitor drowsiness and the adequate feeding of the infant (Kanto 1982). It is not recommended to co-sleep with the baby if you are taking this medication (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).
CAS Number: 57109-90-7
Clorazepate is excreted into breastmilk and appears to accumulate in the serum of breastfed infants. Because the half-life of clorazepate and its active metabolite are long, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. Other agents may be preferred, especially while nursing a newborn or preterm infant.
During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Clorazepate Dipotassium Tablet then you shall inform your doctor, But you should not be worried too much as Clorazepate Dipotassium Tablet comes in category of low risk drug.
Though Clorazepate Dipotassium Tablet dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.
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National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
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