Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg while Breastfeeding
There are high number of clear evidence that breastfeeding provides best nutrition that you can give to your baby. It is also evident that lactation is good for mothers health as well. Evolution has designed breastfeeding in a way that it caters all nutritional need of your child. However modern medicine is quite new for evolution, that is why mothers body is not well prepared to filter unnecessary chemical found in medicines. It becomes a necessity to figure out which drug is safe and which drug is dangerous for your newborn while nursing. In this article we will understand function of Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg and its suitability with breastfeeding.

What is Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg used for?


Epirubicin HCl Injection is indicated as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer [see Clinical Studies (14.1). Epirubicin HCl Injection is an anthracycline topoisomerase II inhibitor indicated as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer (1.1).

Is Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg safe to use while breastfeeding? Can it interfere with growth and development of my kid?

Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg dangerous while breastfeeding
Our analysis of Epirubicin hydrochloride which are active ingredients in Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg indicates that Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg is dangerous to use in breastfeeding. We strongly recommend you to go through detailed analysis of Epirubicin hydrochloride as below and do not use Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg during breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Epirubicin was excreted into the milk of rats treated with 0.50 mg/kg/day of epirubicin during peri- and postnatal periods. It is not known whether this drug is excreted in human milk. Because many drugs, including other anthracyclines, are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Epirubicin HCl, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg Breastfeeding Analsys


Epirubicin hydrochloride while Breastfeeding

Dangerous

CAS Number: 56390-09-1

Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg and breastfeeding

Epirubicin is an antineoplastic from the anthracycline family, with actions similar to doxorubicin but with fewer toxic effects. Since the last update we have not found published data on its excretion in breast milk. Although it has a high volume of distribution, the remaining pharmacokinetic data (not very high molecular weight and protein binding, high pKa and long half-life) make it probable that it will pass into breast milk in quantities that could be significant, as has been seen in another drug from the same therapeutic group, Doxorubicin. Given its serious side effects (cardiotoxicity and myelotoxicity) (Tjuljandin 1990) it is prudent to discontinue breastfeeding during the period in which the drug is still in the mother's body. When possible, detection in the milk of each patient to determine the total elimination of the drug would be the best indicator for resuming breastfeeding between two rounds of chemotherapy. It is known via Pharmacokinetics that after 3 elimination half-lives (T½) 87.5% of the drug is eliminated from the body; after 4 T½ 94%, after 5 T½ 96.9%, after 6 T½ 98.4% and after 7 T½ 99%. Plasma drug concentrations in the body are negligible after 7 T½. In general, a period of five half-lives may be considered a safe waiting period to return to breastfeeding (Anderson 2016). Expert authors recommend waiting 7 to 10 days (between 5 and 7 T½) after the last dose to restart breastfeeding. Meanwhile, express and discard breast milk regularly (Hale 2017 p.330). There may be an increase in the mean half-life in patients with impaired hepatic function (Twelves 1992) or in co-administration with other medication such as paclitaxel (Danesi 2002), docetaxel or dexverapamil (AEMPS 2017, BC Cancer 2017). In these cases, the safety time of interruption of breastfeeding would be increased. Some chemotherapeutics with antibiotic effects may alter the composition of the microbiota (combination of bacteria or bacterial flora) of the milk and the concentration of some of its components (Urbaniak 2014). This possibly occurs briefly with later recovery, with no harmful effects being reported in breastfed infants.


Is Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg safe while breastfeeding

What should I do if I am breastfeeding mother and I am already exposed to Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg?

You should immediately inform your health care provider about Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg usage and your breastfeeding interval after usage of . If you feel baby is having abnormal behavior or any other health issue please call 911 immediately or contact nearest medical emergency center.


My health care provider has asked me to use Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg, what to do?

Please double check with your doctor if he is aware of your breastfeeding stratus, Ask your doctor if there is any safe alternative of Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg. Check with your doctor if you shall temporally stop breastfeeding. You may go for second opinion as well. Still after all of this if your doctor still recommends Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg then go for it as they have access on more detailed medical and scientific information and they understand your individual medical situation much better.


If I am using Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg, will my baby need extra monitoring?

Extreme level of monitoring required as Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg could be dangerous for kid.


Who can I talk to if I have questions about usage of Epirubicin Hydrochloride Epirubicin Hydrochloride 2 Mg in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week