Aripiprazole | Major Pharmaceuticals Breastfeeding

It is a well known fact that breastfeeding is best source of nutrition for infants. Breast milk provides minerals, vitamins and antibodies in most acceptable format when they need it. Nutrition taken by mother passes to breast-milk and same thing applies to medicines taken by mothers. Not all drugs cause problem for baby but some do. Lets analyze if Aripiprazole | Major Pharmaceuticals is safe for baby while breastfed.

What is Aripiprazole | Major Pharmaceuticals used for?

Anagrelide is a platelet reducing agent indicated for the treatment of thrombocythemia, secondary to myeloproliferative neoplasms, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events. (1) •Schizophrenia (14.1) •Acute Treatment of Manic and Mixed Episodes associated with Bipolar I (14.2) •Adjunctive Treatment of Major Depressive Disorder (14.3) •Irritability Associated with Autistic Disorder (14.4) •Treatment of Tourette's disorder (14.5) Aripiprazole Oral Tablets are indicated for the treatment of: •Schizophrenia [see CLINICAL STUDIES (14.1) ] •Acute Treatment of Manic and Mixed Episodes associated with Bipolar I Disorder [see CLINICAL STUDIES (14.2) ] •Adjunctive Treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.3) ] •Irritability Associated with Autistic Disorder [see CLINICAL STUDIES (14.4) ] •Treatment of Tourette's Disorder [see CLINICAL STUDIES (14.5) ]

Aripiprazole | Major Pharmaceuticals while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Aripiprazole | Major Pharmaceuticals low risk for breastfeeding
Aripiprazole | Major Pharmaceuticals contains only one active ingredient that is Aripiprazole. We have analyzed the usage of Aripiprazole in breastfeeding and our analysis suggest that Aripiprazole poses Low risk for infant while breastfeeding and hence Aripiprazole | Major Pharmaceuticals itself shall be considered Low risk item for breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers None.

Aripiprazole | Major Pharmaceuticals Breastfeeding Analsys

Aripiprazole while Breastfeeding

Low Risk

CAS Number: 129722-12-9

ts pharmacokinetic data (low oral bioavailability, large volume of distribution, moderately elevated molecular weight and high plasma protein binding) explains the negligible or zero passage into milk observed (Grover 2015, Nordeng 2014, Watanabe 2011, Lutz 2010, Schlotterbeck 2007). No problems were observed in infants whose mothers were taking it (Nordeng 2014, Tarikh 2014, Lutz 2010). The plasma levels of these infants were undetectable or very low (Watanabe 2011). Its relationship with prolactin is controversial because it lowers prolactin levels and has been used to treat prolactinomas and hyperprolactinemia induced by the use of other antipsychotics (Bakker 2016, Ranjbar 2015, Raghuthaman 2015, Safer 2013, Byerly 2009, Lorenz 2007, Goodnick 2002), but cases of decreased milk production have been reported (Frew 2015, Mendhekar 2006) and hyperprolactinemia triggered by aripiprazole has been reported (Sogawa 2016, Prost 2016, Saraf 2014, Mendhekar 2005, Ruffatti 2005). Due to its slow elimination, it may be worthwhile using other compatible antipsychotics with a shorter half-life, especially during the neonatal period and in case of prematurity (Uguz 2016). Monitor for possible drowsiness in the infant (Hale 2017 p.74).

Aripiprazole | Major Pharmaceuticals Breastfeeding Analsys - 2

Aripiprazole while Breastfeeding

CAS Number: 129722-12-9

Limited information indicates that maternal doses of aripiprazole up to 15 mg daily produce low levels in milk, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[1] Aripiprazole can lower serum prolactin in a dose-related manner, but cases of gynecomastia and galactorrhea have also been reported.

Is Aripiprazole | Major Pharmaceuticals safe while breastfeeding

What should I do if already breastfed my kid after using Aripiprazole | Major Pharmaceuticals?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Aripiprazole | Major Pharmaceuticals then you shall inform your doctor, But you should not be worried too much as Aripiprazole | Major Pharmaceuticals comes in category of low risk drug.

I am nursing mother and my doctor has suggested me to use Aripiprazole | Major Pharmaceuticals, is it safe?

Though Aripiprazole | Major Pharmaceuticals dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.

If I am using Aripiprazole | Major Pharmaceuticals, will my baby need extra monitoring?

Not much

Who can I talk to if I have questions about usage of Aripiprazole | Major Pharmaceuticals in breastfeeding?

National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week