Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] Breastfeeding

Most health expert recommend six month of exclusive breastfeeding but statics suggest that numbers are not good, almost 95% mothers start breastfeeding but this number drops to 40% in first three month and further it drops to 15% till fifth month. Sometime its due to need of medication usage. Because of these statics its important to provide good information on safety of drugs in breastfeeding so that it can be improved when possible. In this FAQ sheet we will discuss about exposure to Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] while breastfeeding. We will also discuss about common side effects and warnings associated with Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x].

What is Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] ?


: TREZIX™ (acetaminophen, caffeine, and dihydrocodeine bitartrate) capsulesare indicated for the relief of moderate to moderately severe pain.

Can I use Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] while breastfeeding?

Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] low risk for breastfeeding
Task to evaluate the effect of Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] is quite difficult as it consist mainly 3 ingredients. However we have analyzed all 3 active ingredients and have reached a conclusion that Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] poses low risk while breastfeeding. Below we have summarized our analysis of each 3 ingredients.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers: Dihydrocodeine bitartrate is secreted into human milk. In women with normal dihydrocodeine metabolism (normal CYP2D6 activity), the amount of dihydrocodeine secreted into human milk is low and dose-dependent. However, some women are ultra-rapid metabolizers of dihydrocodeine. These women achieve higher-than-expected serum levels of dihydrocodeine’s active metabolite, dihydromorphine, leading to higher-than-expected levels of dihydromorphine in breast milk and potentially dangerously high serum dihydromorphine levels in their breastfed infants. Therefore, maternal use of dihydrocodeine can potentially lead to serious adverse reactions, including death, in nursing infants. The risk of infant exposure to dihydrocodeine and morphine through breast milk should be weighed against the benefits of breastfeeding for both the mother and baby. Caution should be exercised when dihydrocodeine is administered to a nursing woman. If a dihydrocodeine containing product is selected, the lowest dose should be prescribed for the shortest period of time to achieve the desired clinical effect. Mothers using dihydrocodeine should be informed about when to seek immediate medical care and how to identify the signs and symptoms of neonatal toxicity, such as drowsiness or sedation, difficulty breastfeeding, breathing difficulties, and decreased tone, in their baby. Nursing mothers who are ultra-rapid metabolizers may also experience overdose symptoms such as extreme sleepiness, confusion or shallow breathing. Prescribers should closely monitor mother-infant pairs and notify treating pediatricians about the use of dihydrocodeine-containing products during breastfeeding (See Warnings). Acetaminophen and caffeine are also excreted in breast milk in small amounts. Because of the potential for serious adverse reactions in nursing infants from this combination product, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] Breastfeeding Analsys


Acetaminophen while Breastfeeding

Safe

CAS Number: 103-90-2

Excreted in very low amount into breast milk. Infant intake may be lower than 4% of usual pediatric dose. The American Academy of Pediatrics rates it as compatible with Breastfeeding.

Caffeine while Breastfeeding

Low Risk

CAS Number: 58-08-2

Trimethylxanthine component which is present in many compounds like decongestant or pain relief drugs (50 to 100 mg per unit) . It is also present in many infusion beverages (coffee, tea, mate, guarana) and other drinks with allegedly energizing properties. See also Coffee, Caffeine (beverages). At a dose higher than 300 mg a-day may induce nervousness and irritability in the infant. Intravenous high doses used to treat post-epidural anesthesia headache within 2-3 days after delivery, before mature breast milk comes, are compatible with breastfeeding. High doses used Intravenously to treat headache related to epidural should be regarded as compatible with breastfeeding only in the 2-3 days before milk comes in. Elimination period may last from few hours in adults, to 3-4 days in the newborn infant. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Dihydrocodeine bitartrate while Breastfeeding

Low Risk

CAS Number: 125-28-0

Used for pain and cough relief. As analgesic it is not more effective than Ibuprofen. The enzyme cytochrome P450-CYP2D6 catalyzes its metabolization into dehydromorphine. On date of latest update relevant data concerning breastfeeding were not found. Product with similar characteristics than Codeine but with lower oral bioavailability which would be advantageous for breastfed infants. Codeine is excreted into breast milk in non-significant amount, however, serious health problems have appeared among off-spring of mothers who are rapid metabolizers from Codeine to Morphine. Discontinue if excessive sedation appears in mother or infant, and, do not administer if such a background in mother or family is present, as there are between 1% and 29% of people who are rapid metabolizers from codeine to morphine with an excess of the gene linked to enzyme P450-CYP2D6.


Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] Breastfeeding Analsys - 2


Acetaminophen while Breastfeeding

CAS Number: 103-90-2

Acetaminophen is a good choice for analgesia, and fever reduction in nursing mothers. Amounts in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare.

Caffeine while Breastfeeding

CAS Number: 58-08-2

Caffeine appears in breastmilk rapidly after maternal ingestion. Insufficient high-quality data are available to make good evidence-based recommendations on safe maternal caffeine consumption.[1] Fussiness, jitteriness and poor sleep patterns have been reported in the infants of mothers with very high caffeine intakes equivalent to about 10 or more cups of coffee daily. Studies in mothers taking 5 cups of coffee daily found no stimulation in breastfed infants 3 weeks of age and older. Some experts feel that a maternal intake limit of 300 mg daily might be a safe level of intake.[2] However, preterm and younger newborn infants metabolize caffeine very slowly and may have serum levels of caffeine and other active caffeine metabolites similar to their mothers' levels,[2][3][4] so a lower intake level preferable in the mothers of these infants. Other sources of caffeine, such as cola and energy drinks, yerba mate or guarana, will have similar dose-related effects on the breastfed infant. Coffee intake of more than 450 mL daily may decrease breastmilk iron concentrations and result in mild iron deficiency anemia in some breastfed infants.[5]

Dihydrocodeine bitartrate while Breastfeeding

CAS Number: 125-28-0

Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system (CNS) depression and even death. Like codeine, pharmacogenetics probably plays a role in the extent of CNS depression. Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. Dihydrocodeine possibly caused severe respiratory depression in one newborn infant whose mother was taking the drug for cough. Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of hydromorphone to a few days at a low dosage with close infant monitoring. If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately. Because there is little published experience with dihydrocodine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.



What should I do if already breastfed my kid after using Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x]?

Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] so you should inform him based on your convenience.


My doctor has prescribed me Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x], what should I do?

Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.


If I am using Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x], will my baby need extra monitoring?

Not much monitoring required while using Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x]


Who can I talk to if I have questions about usage of Trezix | Acetaminophen 6 [hp_x], Caffeine 6 [hp_x], Dihydrocodeine Bitartrate 6 [hp_x] in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week