Bosentan Tablet Breastfeeding

Breast milk is superior in nutrition, It provides resistance against infections and allergies, It is naturally sterile. Despite all the advantages of breastfeeding some mothers choose to pause the breastfeeding in fear of harmful effects of medicines passing in breast milk. Are you wondering about breastfeeding and using Bosentan Tablet ? Know what is Bosentan Tablet and how it can affect your breast milk and whether Bosentan Tablet is safe for your kid or not.

What is Bosentan Tablet used for?


Bosentan Tablets are indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1): in adults to improve exercise ability and to decrease clinical worsening. Studies establishing effectiveness included predominantly patients with WHO Functional Class II-IV symptoms and etiologies of idiopathic or heritable PAH (60%), PAH associated with connective tissue diseases (21%), and PAH associated with congenital heart disease with left-to-right shunts (18%) [see Clinical Studies (14.1)]. Bosentan Tablets are an endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1): in adults to improve exercise ability and to decrease clinical worsening. Studies establishing effectiveness included predominantly patients with WHO Functional Class II-IV symptoms and etiologies of idiopathic or heritable PAH (60%), PAH associated with connective tissue diseases (21%), and PAH associated with congenital heart disease with left-to-right shunts (18%) (1).

Is Bosentan Tablet usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Bosentan Tablet low risk for breastfeeding
Bosentan Tablet contains only one active ingredient that is Bosentan anhydrous. We have analyzed the usage of Bosentan anhydrous in breastfeeding and our analysis suggest that Bosentan anhydrous poses Low risk for infant while breastfeeding and hence Bosentan Tablet itself shall be considered Low risk item for breastfeeding.

Bosentan Tablet Breastfeeding Analsys


Bosentan anhydrous while Breastfeeding

Low Risk

CAS Number: 147536-97-8

Indicated for the treatment of pulmonary arterial hypertension. Pharmacokinetic data (moderately high molecular weight and high percentage of protein binding capacity) make it unlikely a milk passage in significant amounts.Low oral bioavailability hinders its passage from the ingested milk to infant's plasma, except in preterm and immediate neonatal period that may show an increased intestinal permeability. Although no samples have been taken to analyze the concentration in breast milk, a 30 weeks old premature infant who was breastfed for 2-and-a-half months, while his mother was treated with Bosentan and Sildenafil, did not present side-effects. It is approved for Pediatric use from 1-year-old or 10 kg to higher, but there are not published data on neonatal indication. It would be preferred a safer alternative until more data is available about this drug regarding breastfeeding, especially during the neonatal period and in case of prematurity.

Bosentan Tablet Breastfeeding Analsys - 2


Bosentan anhydrous while Breastfeeding

CAS Number: 147536-97-8

There is little published experience with bosentan during breastfeeding. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Is Bosentan Tablet safe while breastfeeding

What if I already have used Bosentan Tablet?

Bosentan Tablet is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Bosentan Tablet so you should inform him based on your convenience.


I am nursing mother and my doctor has suggested me to use Bosentan Tablet, is it safe?

Though Bosentan Tablet dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.


If I am using Bosentan Tablet, will my baby need extra monitoring?

Not much monitoring required while using Bosentan Tablet


Who can I talk to if I have questions about usage of Bosentan Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

Drug Brands with same Active ingredients

Tracleer | Bosentan Tablet