Topiramate Tablet Breastfeeding

For most of the drugs advantages of taking medications overweighs the potential risks however some drugs could be really dangerous for breastfed baby hence every medication shall be considered separately. In this page we will discuss about purpose of Topiramate Tablet and its risk associated with lactation. We will also discuss the usage of Topiramate Tablet and some common side effects associated with Topiramate Tablet.

What is Topiramate Tablet used for?


Topiramate Tablets USP are an antiepileptic (AED) agent indicated for: Monotherapy epilepsy: Initial monotherapy in patients ≥10 years of age with partial onset or primary generalized tonic-clonic seizures (1.1) Adjunctive therapy epilepsy: Adjunctive therapy for adults and pediatric patients (2 to 16 years of age) with partial onset seizures or primary generalized tonic-clonic seizures, and in patients ≥2 years of age with seizures associated with Lennox-Gastaut syndrome (LGS) (1.2) 1.1 Monotherapy Epilepsy Topiramate Tablets USP are indicated as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures. Effectiveness was demonstrated in a controlled trial in patients with epilepsy who had no more than 2 seizures in the 3 months prior to enrollment. Safety and effectiveness in patients who were converted to monotherapy from a previous regimen of other anticonvulsant drugs have not been established in controlled trials [see Clinical Studies (14.1) ]. 1.2 Adjunctive Therapy Epilepsy Topiramate Tablets USP are indicated as adjunctive therapy for adults and pediatric patients ages 2 to 16 years with partial onset seizures or primary generalized tonic-clonic seizures, and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome [see Clinical Studies (14.1) ]

Is Topiramate Tablet usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Topiramate Tablet safe for breastfeeding
Active ingredient in Topiramate Tablet is Topiramate and based on our analysis of Topiramate it appears that using Topiramate Tablet is safe in breastfeeding. Below is analysis of Topiramate while breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Limited data on 5 breastfeeding infants exposed to topiramate showed infant plasma topiramate levels equal to 10-20% of the maternal plasma level. The effects of this exposure on infants are unknown. Caution should be exercised when administered to a nursing woman.

Topiramate Tablet Breastfeeding Analsys


Topiramate while Breastfeeding

Safe

CAS Number: 97240-79-4

Anticonvulsant used for treatment of epilepsy and migraine prophylaxis. It is moderately excreted into breast milk with the infant receiving just over 10% of the maternal weight-adjusted dose. Neither clinical nor psychomotor developmental effects have been observed in infants whose mothers were treated. Only a possibly related case of gastroenteritis that resolved after discontinuation of mother’s medication.Plasma levels of infants whose mothers were treated with topiramate have shown to be undetectable or pretty below (<1 mg / L) the recommended therapeutic level (5-20 mg / L). Check up the occurrence of diarrhea, irritability and lethargy in infants


Topiramate Tablet Breastfeeding Analsys - 2


Topiramate while Breastfeeding

CAS Number: 97240-79-4

Limited information indicates that maternal doses of topiramate up to 200 mg daily produce relatively low levels in infant serum. Monitor the infant for diarrhea, drowsiness, irritability, adequate weight gain, and developmental milestones, especially in younger, exclusively breastfed infants and when using combinations of anticonvulsant or psychotropic drugs.



What should I do if I am breastfeeding mother and I am already exposed to Topiramate Tablet?

As usage of Topiramate Tablet is mostly safe while breastfeeding hence there should not be any concern. In case of any change in behavior or health of your baby you should inform your health care provider about usage of Topiramate Tablet else no further action is required.


I am nursing mother and my doctor has suggested me to use Topiramate Tablet, is it safe?

Definitely, Topiramate Tablet is safe in lactation for baby. No wonder your doctor has recommended it.


If I am using Topiramate Tablet, will my baby need extra monitoring?

No extra baby monitoring required while mother is using Topiramate Tablet


Who can I talk to if I have questions about usage of Topiramate Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week