Is Carboplatin Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Carboplatin? Is Carboplatin safe for nursing mother and child? Does Carboplatin extracts into breast milk? Does Carboplatin has any long term or short term side effects on infants? Can Carboplatin influence milk supply or can Carboplatin decrease milk supply in lactating mothers?
Carboplatin lactation summary
- DrLact safety Score for Carboplatin is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of Carboplatin may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that Carboplatin may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using Carboplatin .
- Usage of Carboplatin is in contradiction to breastfeeding hence if it is must to use Carboplatin and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Carboplatin usage in lactation
Resuming breastfeeding is likely safe when milk platinum levels are not detected (30 days).
Answer by DrLact: About Carboplatin usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as carboplatin.[1] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration of abstinence is not clear. In one case, carboplatin was still detectable in milk 13 days after a dose of 2.9 mg/kg. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[3]
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Paclitaxel(Dangerous)
Hydroxyurea(Low Risk)
Fluorouracil(Dangerous)
Etoposide(Dangerous)
Gemcitabine(Dangerous)
Alemtuzumab(Low Risk)
Nivolumab(Unsafe)
Doxorubicin(Dangerous)
Rituximab(Low Risk)
Vinblastine(Dangerous)
Cyclophosphamide(Dangerous)
Bevacizumab(Low Risk)
Bleomycin(Dangerous)
Docetaxel(Dangerous)
Cisplatin(Unsafe)
Pazopanib(Unsafe)
Vinorelbine(Dangerous)
Busulfan(Dangerous)
Trastuzumab(Unsafe)
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Thioguanine(Dangerous)
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Letrozole(Dangerous)
Dasatinib(Unsafe)
Exemestane(Dangerous)
Vincristine(Dangerous)
Nilotinib(Unsafe)
Tamoxifen(Dangerous)
Dactinomycin(Dangerous)
Ipilimumab(Unsafe)
Mitoxantrone(Dangerous)
Cetuximab(Unsafe)
Mercaptopurine(Safe)
Carboplatin(Dangerous)