Is Abciximab Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Abciximab? Is Abciximab safe for nursing mother and child? Does Abciximab extracts into breast milk? Does Abciximab has any long term or short term side effects on infants? Can Abciximab influence milk supply or can Abciximab decrease milk supply in lactating mothers?
Abciximab lactation summary
- DrLact safety Score for Abciximab is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Abciximab may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Abciximab may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Abciximab low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Abciximab We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Abciximab usage in lactation
Monoclonal antibody fragment that binds to platelet receptors inhibiting platelet aggregation. Used to treat angioplasty and unstable angina. Since the last update we have not found any published data on its excretion in breast milk. Its pharmacokinetic data: very high molecular weight, high percentage of platelet binding (Harder 1999) and short half-life, make it very unlikely it will pass into breast milk in significant amounts. Due to its protein nature, it deteriorates in the gastrointestinal tract, not being absorbed. This low oral bioavailability would make it difficult for it to pass to the infant’s plasma ingesting breast milk, except in preterm infants and in the immediate neonatal period when there may be increased intestinal permeability.
Answer by DrLact: About Abciximab usage in lactation
No information is available on the clinical use of abciximab during breastfeeding. Because abciximab is a large protein molecule with a molecular weight of 47,615, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, abciximab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.
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