Is BRN 0454188 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use BRN 0454188? Is BRN 0454188 safe for nursing mother and child? Does BRN 0454188 extracts into breast milk? Does BRN 0454188 has any long term or short term side effects on infants? Can BRN 0454188 influence milk supply or can BRN 0454188 decrease milk supply in lactating mothers?
BRN 0454188 lactation summary
- DrLact safety Score for BRN 0454188 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of BRN 0454188 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that BRN 0454188 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of BRN 0454188 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using BRN 0454188 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About BRN 0454188 usage in lactation
At latest update no published data were found on excretion into breast milk. Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.Its high plasma protein binding capacity makes it highly unlikely a passage into milk.A low oral bioavailability hinders the passage from ingested milk toward the infant’s plasma except in case of premature babies and/or in the immediate neonatal period, in which an increased intestinal permeability may appear. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.
Answer by DrLact: About BRN 0454188 usage in lactation
Because no information is available on the use of BRN 0454188 during breastfeeding, an alternate drug may be preferred.
Alternate Drugs
Amlodipine(Low Risk)
Felodipine(Low Risk)
Carvedilol(Low Risk)
Methyldopa(Safe)
Bisoprolol(Low Risk)
Nebivolol(Unsafe)
Enalapril(Safe)
Lisinopril(Low Risk)
Nitrendipine(Safe)
Atenolol(Unsafe)
Nicardipine(Safe)
Valsartan(Low Risk)
Acebutolol(Unsafe)
Timolol(Safe)
Terazosin(Unsafe)
Diltiazem(Safe)
Isradipine(Low Risk)
Sotalol(Low Risk)
Nisoldipine(Low Risk)
Telmisartan(Unsafe)
Indapamide(Low Risk)
Propranolol(Safe)
Prazosin(Unsafe)
Chlorthalidone(Dangerous)
Verapamil(Safe)
Chlorothiazide(Safe)
Hydrochlorothiazide(Safe)
Nimodipine(Safe)
Losartan(Low Risk)
Captopril(Safe)
Trandolapril(Dangerous)
Nadolol(Unsafe)
Irbesartan(Unsafe)
Bumetanide(Low Risk)
Torsemide(Low Risk)
Metoprolol(Safe)
Spironolactone(Safe)
Hydralazine(Safe)
Nifedipine(Safe)
Bendroflumethiazide(Unsafe)
Reserpine(Unsafe)
Furosemide(Low Risk)
Levobunolol(Low Risk)
Doxazosin(Safe)
Eprosartan(Low Risk)
Benazepril(Safe)
Ramipril(Low Risk)
Fosinopril(Low Risk)
Labetalol(Safe)
Bosentan(Low Risk)
Minoxidil(Safe)
Guanfacine(Low Risk)
Nitrendipine(Safe)
Nicardipine(Safe)
Diltiazem(Safe)
Isradipine(Low Risk)
Nisoldipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)
Nifedipine(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Nitroglycerin(Safe)
Nitrendipine(Safe)
Nebivolol(Unsafe)
Nicardipine(Safe)
Diltiazem(Safe)
Isradipine(Low Risk)
Nisoldipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)
Hydralazine(Safe)
Nifedipine(Safe)
Minoxidil(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Sildenafil(Safe)