Is 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester? Is 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester safe for nursing mother and child? Does 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester extracts into breast milk? Does 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester has any long term or short term side effects on infants? Can 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester influence milk supply or can 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester decrease milk supply in lactating mothers?
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester lactation summary
- DrLact safety Score for 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester usage in lactation
It is excreted into breast milk in clinically non-significant amount possibly due to its high plasma protein binding capacity. Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.
Answer by DrLact: About 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester usage in lactation
Based on limited data, it is unlikely that 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester will reach the infant in clinically important amounts. However, it may be preferable to use another agent drug for which more safety information is available.
Alternate Drugs
Chlorothiazide(Safe)
Losartan(Low Risk)
Captopril(Safe)
Trandolapril(Dangerous)
Hydrochlorothiazide(Safe)
Nimodipine(Safe)
Irbesartan(Unsafe)
Bumetanide(Low Risk)
Torsemide(Low Risk)
Nadolol(Unsafe)
Spironolactone(Safe)
Hydralazine(Safe)
Metoprolol(Safe)
Bendroflumethiazide(Unsafe)
Reserpine(Unsafe)
Furosemide(Low Risk)
Nifedipine(Safe)
Eprosartan(Low Risk)
Benazepril(Safe)
Ramipril(Low Risk)
Fosinopril(Low Risk)
Levobunolol(Low Risk)
Doxazosin(Safe)
Bosentan(Low Risk)
Labetalol(Safe)
Minoxidil(Safe)
Guanfacine(Low Risk)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Carvedilol(Low Risk)
Bisoprolol(Low Risk)
Methyldopa(Safe)
Nebivolol(Unsafe)
Enalapril(Safe)
Nitrendipine(Safe)
Atenolol(Unsafe)
Lisinopril(Low Risk)
Valsartan(Low Risk)
Acebutolol(Unsafe)
Nicardipine(Safe)
Terazosin(Unsafe)
Diltiazem(Safe)
Timolol(Safe)
Nisoldipine(Low Risk)
Telmisartan(Unsafe)
Isradipine(Low Risk)
Sotalol(Low Risk)
Prazosin(Unsafe)
Chlorthalidone(Dangerous)
Verapamil(Safe)
Indapamide(Low Risk)
Propranolol(Safe)
Cinnarizine(Low Risk)
Nimodipine(Safe)
Nifedipine(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Nitrendipine(Safe)
Nicardipine(Safe)
Diltiazem(Safe)
Nisoldipine(Low Risk)
Isradipine(Low Risk)
Verapamil(Safe)
Hydralazine(Safe)
Nifedipine(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Minoxidil(Safe)
Sildenafil(Safe)
Nitroglycerin(Safe)
Nitrendipine(Safe)
Nebivolol(Unsafe)
Nicardipine(Safe)
Diltiazem(Safe)
Nisoldipine(Low Risk)
Isradipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)