Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 3145? Is HSDB 3145 safe for nursing mother and child? Does HSDB 3145 extracts into breast milk? Does HSDB 3145 has any long term or short term side effects on infants? Can HSDB 3145 influence milk supply or can HSDB 3145 decrease milk supply in lactating mothers?

HSDB 3145 lactation summary

HSDB 3145 is safe in breastfeeding
  • DrLact safety Score for HSDB 3145 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of HSDB 3145 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that HSDB 3145 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of HSDB 3145 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 3145 usage in lactation

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms non-absorbable chelate compounds with milk calcium. It is not convenient its long-term use (more than 3-4 weeks) since damage on bone growth plates, teeth discoloration, or alteration of intestinal flora may occur. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Answer by DrLact: About HSDB 3145 usage in lactation

A number of reviews have stated that tetracyclines are contraindicated during breastfeeding because of possible staining of infants' dental enamel or bone deposition of tetracyclines. However, a close examination of available literature indicates that there is not likely to be harm in short-term use of HSDB 3145 during lactation because milk levels are low and absorption by the infant is inhibited by the calcium in breastmilk. Short-term use of HSDB 3145 is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses during nursing. Monitor the infant for rash and for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash).

HSDB 3145 Side Effects in Breastfeeding

No adverse effects were noted in an unspecified number of breastfed infants whose mothers were taking oral HSDB 3145 1.5 or 2 g daily for 3 days. Ages of the infants and extent of breastfeeding were not stated.[2]

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.