Is NCI-C56473 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use NCI-C56473? Is NCI-C56473 safe for nursing mother and child? Does NCI-C56473 extracts into breast milk? Does NCI-C56473 has any long term or short term side effects on infants? Can NCI-C56473 influence milk supply or can NCI-C56473 decrease milk supply in lactating mothers?

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms non-absorbable chelate compounds with milk calcium. It is not convenient its long-term use (more than 3-4 weeks) since damage on bone growth plates, teeth discoloration, or alteration of intestinal flora may occur. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

A number of reviews have stated that tetracyclines are contraindicated during breastfeeding because of possible staining of infants' dental enamel or bone deposition of tetracyclines. However, a close examination of available literature indicates that there is not likely to be harm in short-term use of NCI-C56473 during lactation because milk levels are low and absorption by the infant is inhibited by the calcium in breastmilk. Short-term use of NCI-C56473 is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses during nursing. Monitor the infant for rash and for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash).

No adverse effects were noted in an unspecified number of breastfed infants whose mothers were taking oral NCI-C56473 1.5 or 2 g daily for 3 days. Ages of the infants and extent of breastfeeding were not stated.[2]