Question

I am a breastfeeding mother and i want to know if it is safe to use NCI-C56473? Is NCI-C56473 safe for nursing mother and child? Does NCI-C56473 extracts into breast milk? Does NCI-C56473 has any long term or short term side effects on infants? Can NCI-C56473 influence milk supply or can NCI-C56473 decrease milk supply in lactating mothers?

NCI-C56473 lactation summary

NCI-C56473 is safe in breastfeeding
  • DrLact safety Score for NCI-C56473 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of NCI-C56473 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that NCI-C56473 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of NCI-C56473 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NCI-C56473 usage in lactation

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms non-absorbable chelate compounds with milk calcium. It is not convenient its long-term use (more than 3-4 weeks) since damage on bone growth plates, teeth discoloration, or alteration of intestinal flora may occur. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Answer by DrLact: About NCI-C56473 usage in lactation

A number of reviews have stated that tetracyclines are contraindicated during breastfeeding because of possible staining of infants' dental enamel or bone deposition of tetracyclines. However, a close examination of available literature indicates that there is not likely to be harm in short-term use of NCI-C56473 during lactation because milk levels are low and absorption by the infant is inhibited by the calcium in breastmilk. Short-term use of NCI-C56473 is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses during nursing. Monitor the infant for rash and for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash).

NCI-C56473 Side Effects in Breastfeeding

No adverse effects were noted in an unspecified number of breastfed infants whose mothers were taking oral NCI-C56473 1.5 or 2 g daily for 3 days. Ages of the infants and extent of breastfeeding were not stated.[2]

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.