Is Dacomitinib Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Dacomitinib? Is Dacomitinib safe for nursing mother and child? Does Dacomitinib extracts into breast milk? Does Dacomitinib has any long term or short term side effects on infants? Can Dacomitinib influence milk supply or can Dacomitinib decrease milk supply in lactating mothers?
Answer by DrLact: About Dacomitinib usage in lactation
No information is available on the clinical use of dacomitinib during breastfeeding. Because dacomitinib is 98% bound to plasma proteins, the amount in milk is likely to be low. However, because of its potential toxicity in the breastfed infant and its half-life of 70 hours, the manufacturer recommends that breastfeeding be discontinued during dacomitinib therapy and for at least 17 days after the last dose.
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