Is PZC Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use PZC? Is PZC safe for nursing mother and child? Does PZC extracts into breast milk? Does PZC has any long term or short term side effects on infants? Can PZC influence milk supply or can PZC decrease milk supply in lactating mothers?

PZC lactation summary

DrLact safety Score for PZC is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of PZC is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that PZC does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of PZC safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About PZC usage in lactation

One reportedly case of use by a mother for 3,5 months (8 - 12 mg x 2 / daily) without harm effects on the child. Check-up for lethargy or dyskinetic symptoms.

Answer by DrLact: About PZC usage in lactation

Limited information indicates that maternal doses of PZC up to 24 mg daily produce low levels in milk. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Monitor the infant for excessive drowsiness during breastfeeding and for developmental milestones, especially if other antipsychotics are used concurrently.

PZC Side Effects in Breastfeeding

One infant was breastfed from 1 month to 4.5 months of age during maternal intake of PZC 16 mg daily. The infant grew normally and no adverse drug effects were seen.[1]

PZC Possible Effects in Breastfeeding

Galactorrhea has been reported with PZC.[2][3] Hyperprolactinemia appears to be the cause of the galactorrhea.[4][5][6] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.