Is BRN 0221083 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use BRN 0221083? Is BRN 0221083 safe for nursing mother and child? Does BRN 0221083 extracts into breast milk? Does BRN 0221083 has any long term or short term side effects on infants? Can BRN 0221083 influence milk supply or can BRN 0221083 decrease milk supply in lactating mothers?

Small occasional doses of BRN 0221083 would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

There are no reports of infants breastfed during maternal therapy with BRN 0221083. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.