Is Peginterferon Alfa Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Peginterferon Alfa? Is Peginterferon Alfa safe for nursing mother and child? Does Peginterferon Alfa extracts into breast milk? Does Peginterferon Alfa has any long term or short term side effects on infants? Can Peginterferon Alfa influence milk supply or can Peginterferon Alfa decrease milk supply in lactating mothers?

Although no information is available on peginterferon alfa in breastmilk, the levels of conventional interferon alfa in breastmilk are minuscule. In addition, because interferon is poorly absorbed orally, it is not likely to reach the bloodstream of the infant. It is unlikely that peginterferon alfa use by a nursing mother presents any serious risk to the breastfed infant. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of the related endogenous interferon-gamma by an average about 10%.[1] For use in treating maternal hepatitis B, no difference exist in infection rates between breast-fed and formula-fed infants born to hepatitis B-infected women, as long as the infant receives hepatitis B immune globulin and hepatitis B vaccine at birth. Mothers with hepatitis B are encouraged to breastfeed their infants after their infants receive these preventative measures.[2][3]

One infant was born to a mother who received 3 million units of interferon alfa-2a subcutaneously 3 times weekly during pregnancy and postpartum for essential thrombocytopenia. Her infant was breastfed for 2 weeks postpartum before bilateral mastitis caused the mother to terminate nursing. The infant reportedly thrived, although specific measures were not mentioned.[6]