Is Prednicarbate Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Prednicarbate? Is Prednicarbate safe for nursing mother and child? Does Prednicarbate extracts into breast milk? Does Prednicarbate has any long term or short term side effects on infants? Can Prednicarbate influence milk supply or can Prednicarbate decrease milk supply in lactating mothers?

High potency topical steroid. Since the last update we have not found published data on its excretion in breast milk. Because of a low absorption through skin, 0.1 - 3% (Dermik 2010, Novag 1998), significant excretion into breast milk is unlikely. Whenever a treatment for nipple eczema or dermatitis is required the lowest potency steroid compound should be used (hydrocortisone). It should be applied right after the feed to make sure it has disappeared before the next nursing occurs. Otherwise, wipe cream out with a clean gauze. Do not continuously use for longer than a week. Reportedly, a case of mineral-steroid toxicity has occurred due to continuous use of cream on the nipple (De Stefano 1983). It is advisable to avoid the application to the nipple of creams, gels and other topical products containing paraffin (mineral oil) so that the infant does not absorb them (Concin 2008, Noti 2003).

Topical prednicarbate has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids may cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only the lower potency corticosteroids should be used on the nipple or areola where the infant could directly ingest the drugs from the skin. Only water-miscible cream products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1] Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is being applied to the breast or nipple area.

Topical application of a corticosteroid with relatively high mineralocorticoid activity (isofluprednone acetate) to the mother's nipples resulted in prolonged QT interval, cushingoid appearance, severe hypertension, decreased growth and electrolyte abnormalities in her 2-month-old breastfed infant. The mother had used the cream since birth for painful nipples.[2]