Is Nitroprusside Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Nitroprusside? Is Nitroprusside safe for nursing mother and child? Does Nitroprusside extracts into breast milk? Does Nitroprusside has any long term or short term side effects on infants? Can Nitroprusside influence milk supply or can Nitroprusside decrease milk supply in lactating mothers?

Breastmilk levels of nitroprusside sodium have not been measured after exogenous administration. Because of its short half-life of 2 minutes, it is unlikely to appear in breastmilk. However, its toxic metabolite, thiocyanate, is excreted into milk and can be directly toxic to the infant as well as inhibiting iodide transport into breastmilk. Cyanide is another toxic metabolite of nitroprusside that may enter breastmilk. An alternate drug is therefore preferred, during breastfeeding. If use of nitroprusside sodium is unavoidable, the mother should refrain from breastfeeding.

Several studies have found that breastmilk iodine levels are inversely related to the mothers' blood thiocyanate levels, probably through inhibition of the Na/I symporter by thiocyanate.[6][7][8][9] However, a recent study failed to demonstrate such a correlation. The authors felt that the effect of thiocyanate on iodine transport may be less pronounced than previously reported.[5] These low breastmilk iodine levels might pose a risk of hypothyroidism to breastfed infants whose mothers have low iodine intake.[5][6][7][8][9]