Question

I am a breastfeeding mother and i want to know if it is safe to use Tofacitinib? Is Tofacitinib safe for nursing mother and child? Does Tofacitinib extracts into breast milk? Does Tofacitinib has any long term or short term side effects on infants? Can Tofacitinib influence milk supply or can Tofacitinib decrease milk supply in lactating mothers?

Answer by DrLact: About Tofacitinib usage in lactation

No information is available on the clinical use of tofacitinib during breastfeeding. If tofacitinib is required by the mother, it is not a reason to discontinue breastfeeding.[1] However, until more data become available, tofacitinib should be used with caution during breastfeeding and an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[2] The manufacturer recommends that breastfeeding be discontinued during tofacitinib therapy and for 18 hours after the last dose of Xeljanz or 36 hours after the last dose of Xeljanz XR.

Alternate Drugs

Tocilizumab(Low Risk)
Anakinra(Low Risk)
Methotrexate(Low Risk)
Abatacept(Low Risk)
Rituximab(Low Risk)
Penicillamine(Low Risk)
Auranofin(Low Risk)
Leflunomide(Dangerous)
Dasatinib(Unsafe)
Orlistat(Low Risk)
Gemcitabine(Dangerous)
Nilotinib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Pazopanib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Pazopanib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Pazopanib(Unsafe)
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