Question

I am a breastfeeding mother and i want to know if it is safe to use SKF 4657? Is SKF 4657 safe for nursing mother and child? Does SKF 4657 extracts into breast milk? Does SKF 4657 has any long term or short term side effects on infants? Can SKF 4657 influence milk supply or can SKF 4657 decrease milk supply in lactating mothers?

SKF 4657 lactation summary

SKF 4657 is unsafe in breastfeeding
  • DrLact safety Score for SKF 4657 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of SKF 4657 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that SKF 4657 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using SKF 4657 .
  • It is recommended to evaluate the advantage of not breastfeeding while using SKF 4657 Vs not using SKF 4657 And continue breastfeeding.
  • While using SKF 4657 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About SKF 4657 usage in lactation

May be a cause of galactorhrea by stimulting release of prolactin. Not commercially available in Spain

Answer by DrLact: About SKF 4657 usage in lactation

Based on minimal excretion of other phenothiazine derivatives, it appears that occasional short-term use of SKF 4657 for the treatment of nausea and vomiting poses little risk to the breastfed infant.

SKF 4657 Possible Effects in Breastfeeding

Galactorrhea has been reported with SKF 4657.[1] Hyperprolactinemia appears to be the cause of the galactorrhea.[2][3][4] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.