Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-668Z8C33LU? Is UNII-668Z8C33LU safe for nursing mother and child? Does UNII-668Z8C33LU extracts into breast milk? Does UNII-668Z8C33LU has any long term or short term side effects on infants? Can UNII-668Z8C33LU influence milk supply or can UNII-668Z8C33LU decrease milk supply in lactating mothers?

UNII-668Z8C33LU lactation summary

UNII-668Z8C33LU is unsafe in breastfeeding
  • DrLact safety Score for UNII-668Z8C33LU is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of UNII-668Z8C33LU may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-668Z8C33LU may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using UNII-668Z8C33LU .
  • It is recommended to evaluate the advantage of not breastfeeding while using UNII-668Z8C33LU Vs not using UNII-668Z8C33LU And continue breastfeeding.
  • While using UNII-668Z8C33LU Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-668Z8C33LU usage in lactation

Meglitinide drugs stimulate secretion of endogen insulin.There is a potential risk of hypoglucemia.Oral anti-diabetic drugs are useless for treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower glucemia level. See section on Maternal diabetes mellitus

Answer by DrLact: About UNII-668Z8C33LU usage in lactation

No information is available on the use of UNII-668Z8C33LU during breastfeeding. UNII-668Z8C33LU is a weak acid that is over 98% protein bound, so it is unlikely to pass into breastmilk in clinically important amounts. If UNII-668Z8C33LU is required by the mother, it is not a reason to discontinue breastfeeding. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with UNII-668Z8C33LU.[1] However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.