Is UNII-L6UH7ZF8HC Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-L6UH7ZF8HC? Is UNII-L6UH7ZF8HC safe for nursing mother and child? Does UNII-L6UH7ZF8HC extracts into breast milk? Does UNII-L6UH7ZF8HC has any long term or short term side effects on infants? Can UNII-L6UH7ZF8HC influence milk supply or can UNII-L6UH7ZF8HC decrease milk supply in lactating mothers?

UNII-L6UH7ZF8HC and its metabolite (Paliperidone) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea.

Limited information indicates that maternal UNII-L6UH7ZF8HC doses of up to 6 mg daily produce low levels in milk. Because there is little published experience with UNII-L6UH7ZF8HC during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Systematic reviews of second-generation antipsychotics concluded that UNII-L6UH7ZF8HC seemed to be a second-line agent during breastfeeding because of the limited data available and higher excretion into milk relative to other agents.[1][2]

One woman took UNII-L6UH7ZF8HC 4 mg daily during breastfeeding. Her infant showed no developmental abnormalities on examinations up to 9 months of age. Another mother took UNII-L6UH7ZF8HC 6 mg daily during breastfeeding. Her infant showed no developmental abnormalities on examinations up to 12 months of age.[7] Two women taking UNII-L6UH7ZF8HC 4 mg and 1.5 mg daily breastfed their infants of 3.3 months and 6 weeks of age, respectively, were achieving normal developmental milestones and had no adverse effects reported.[4] A 1 week postpartum woman was started on UNII-L6UH7ZF8HC 2 mg daily and increased after 10 days to a dosage of 3 mg daily. She breastfed her infant 6 times daily. The infant was observed for 5 weeks of inpatient therapy and judged normal by a pediatric neurologist. No sedation or other adverse effects were observed in the infant. After 3 months of treatment with UNII-L6UH7ZF8HC, the mother and infant were judged to be well.[5] An infant had been exclusively breastfed for 3 months during maternal therapy with UNII-L6UH7ZF8HC 1 mg daily. A pediatric examination found the infant to have no neurological or physical abnormalities, and appeared to interact appropriately.[6] In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. One mother who was taking 0.75 mg of UNII-L6UH7ZF8HC daily, flurazepam 15 mg daily, clonazepam 0.25 mg twice daily, and 1 mg of bupropion daily reported sedation in her breastfed infant.[8]

UNII-L6UH7ZF8HC has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[9][10][11][12][13][14][15] In one case, euprolactinemic gynecomastia and galactorrhea occurred in a 19-year-old man who was also taking fluvoxamine.[16] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.