Is Secukinumab Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Secukinumab? Is Secukinumab safe for nursing mother and child? Does Secukinumab extracts into breast milk? Does Secukinumab has any long term or short term side effects on infants? Can Secukinumab influence milk supply or can Secukinumab decrease milk supply in lactating mothers?

Human IgG1 / k monoclonal antibody with capacity for binding to interleukin 17A (IL-17A) by blocking and inhibiting the release of proinflammatory cytokines. It is used on the treatment of Plaque Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis. It is being studied as a treatment of Rheumatoid Arthritis and Uveitis. At latest update relevant published data on excretion into breast milk were not found. Any excretion into breastmilk in a significant amount seems very unlikely because it does not reach a high plasma levels (EMA 2016: 27 to 55 mg / L), has a very high molecular weight and a high binding capacity to plasma proteins. Its low oral bioavailability suggests that the passage to infants' plasma through the ingested breast milk would be nil or low, except in preterm infants and immediate neonatal period, for which there may be a greater intestinal absorption. It is well tolerated without serious side effects which most frequently are mild upper respiratory symptoms and mild diarrhea.

No information is available on the clinical use of secukinumab during breastfeeding. Because secukinumab is a large protein molecule with a molecular weight of 151,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, secukinumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.