Is UNII-2I4BC502BT Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-2I4BC502BT? Is UNII-2I4BC502BT safe for nursing mother and child? Does UNII-2I4BC502BT extracts into breast milk? Does UNII-2I4BC502BT has any long term or short term side effects on infants? Can UNII-2I4BC502BT influence milk supply or can UNII-2I4BC502BT decrease milk supply in lactating mothers?
UNII-2I4BC502BT lactation summary
- DrLact safety Score for UNII-2I4BC502BT is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-2I4BC502BT is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-2I4BC502BT does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-2I4BC502BT safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-2I4BC502BT usage in lactation
Long-acting bronchodilator.
At latest update no published data on excretion into breastmilk were found.
Because of a high plasma protein-binding capacity and very low or undetectable plasma concentrations observed after inhalation (Cazzola 2002, AEMPS 2012) the excretion into breastmilk in significant amounts is unlikely.
Its low oral bioavailability would hamper the pass to the infant’s plasma through the breastmilk ingested.
Experts and scientific societies consider the use of UNII-2I4BC502BT during breastfeeding as devoid of risk for the infant (Ellsworth 1994, McDonald 1996, Nelson 2001, National Asthma Education 2004).
Terbutaline (see specific info), a molecule related to the same group of drugs, is excreted in non-significant amounts into breastmilk.
Answer by DrLact: About UNII-2I4BC502BT usage in lactation
Although no published data exist on the use of UNII-2I4BC502BT by mouth or inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[1] The authors of several reviews agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[2][3][4][5]
Alternate Drugs
Levalbuterol(Safe)
Theophylline(Safe)
Albuterol(Safe)
Arfomoterol(Low Risk)
Isoetharine(Safe)
Zafirlukast(Low Risk)
Formoterol(Safe)
Salmeterol(Safe)
Nedocromil(Safe)
Fluticasone, Inhaled(Safe)
Montelukast(Safe)
Flunisolide(Safe)
Pirbuterol(Safe)
Ipratropium(Safe)
Dyphylline(Safe)
Omalizumab(Low Risk)
Cromolyn(Safe)
Aminophylline(Safe)
Albuterol(Safe)
Arfomoterol(Low Risk)
Isoetharine(Safe)
Terbutaline(Safe)
Salmeterol(Safe)
Formoterol(Safe)
Pirbuterol(Safe)
Levalbuterol(Safe)
Theophylline(Safe)
Arfomoterol(Low Risk)
Albuterol(Safe)
Isoetharine(Safe)
Terbutaline(Safe)
Salmeterol(Safe)
Formoterol(Safe)
Pirbuterol(Safe)
Ipratropium(Safe)
Glycopyrrolate(Unsafe)
Dyphylline(Safe)
Atropine(Safe)
Aminophylline(Safe)
Epinephrine(Safe)
Levalbuterol(Safe)