Question

I am a breastfeeding mother and i want to know if it is safe to use BRN 0057767? Is BRN 0057767 safe for nursing mother and child? Does BRN 0057767 extracts into breast milk? Does BRN 0057767 has any long term or short term side effects on infants? Can BRN 0057767 influence milk supply or can BRN 0057767 decrease milk supply in lactating mothers?

BRN 0057767 lactation summary

BRN 0057767 is safe in breastfeeding
  • DrLact safety Score for BRN 0057767 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of BRN 0057767 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that BRN 0057767 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of BRN 0057767 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About BRN 0057767 usage in lactation

A diuretic which is antagonist of Aldosterone receptor and a potassium-sparing drug. Excretion into breast milk is clinically non-significant and without side-effects observed in breastfed infants of treated mothers. A medication which is used for treatment of infants even in the neonatal period. It decreases slightly the secretion of Prolactin, however, instead other diuretic drugs, a suppressive effect on lactation has not been reported. The American Academy of Pediatrics (2001) rates it as Medication Usually Compatible With Breastfeeding. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About BRN 0057767 usage in lactation

BRN 0057767 appears acceptable to use during breastfeeding.

BRN 0057767 Side Effects in Breastfeeding

In 17-day-old breastfed (extent not stated) infant whose mother was taking 25 mg of BRN 0057767 4 times daily since pregnancy, serum sodium and potassium remained normal.[1]BRN 0057767 75 mg every other day was taken orally by a mother while nursing a newborn. She was also taking 400 mg of bretylium tosylate every 8 hours, atenolol 25 mg daily, propranolol 20 mg 3 times a day, and multivitamin, potassium and magnesium supplements. Jaundice, thought to be unrelated to the drug, occurred at 60 hours of age, but resolved. The infant had appropriate weight gain and development during the first 4 months of life.[2]

BRN 0057767 Possible Effects in Breastfeeding

Intense diuresis can suppress lactation;[3][4] however, it is unlikely that BRN 0057767 alone is sufficiently potent to cause this effect. BRN 0057767 can also cause gynecomastia.[5]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.