Question

I am a breastfeeding mother and i want to know if it is safe to use EINECS 200-133-6? Is EINECS 200-133-6 safe for nursing mother and child? Does EINECS 200-133-6 extracts into breast milk? Does EINECS 200-133-6 has any long term or short term side effects on infants? Can EINECS 200-133-6 influence milk supply or can EINECS 200-133-6 decrease milk supply in lactating mothers?

EINECS 200-133-6 lactation summary

EINECS 200-133-6 is safe in breastfeeding
  • DrLact safety Score for EINECS 200-133-6 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of EINECS 200-133-6 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that EINECS 200-133-6 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of EINECS 200-133-6 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About EINECS 200-133-6 usage in lactation

A diuretic which is antagonist of Aldosterone receptor and a potassium-sparing drug. Excretion into breast milk is clinically non-significant and without side-effects observed in breastfed infants of treated mothers. A medication which is used for treatment of infants even in the neonatal period. It decreases slightly the secretion of Prolactin, however, instead other diuretic drugs, a suppressive effect on lactation has not been reported. The American Academy of Pediatrics (2001) rates it as Medication Usually Compatible With Breastfeeding. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About EINECS 200-133-6 usage in lactation

EINECS 200-133-6 appears acceptable to use during breastfeeding.

EINECS 200-133-6 Side Effects in Breastfeeding

In 17-day-old breastfed (extent not stated) infant whose mother was taking 25 mg of EINECS 200-133-6 4 times daily since pregnancy, serum sodium and potassium remained normal.[1]EINECS 200-133-6 75 mg every other day was taken orally by a mother while nursing a newborn. She was also taking 400 mg of bretylium tosylate every 8 hours, atenolol 25 mg daily, propranolol 20 mg 3 times a day, and multivitamin, potassium and magnesium supplements. Jaundice, thought to be unrelated to the drug, occurred at 60 hours of age, but resolved. The infant had appropriate weight gain and development during the first 4 months of life.[2]

EINECS 200-133-6 Possible Effects in Breastfeeding

Intense diuresis can suppress lactation;[3][4] however, it is unlikely that EINECS 200-133-6 alone is sufficiently potent to cause this effect. EINECS 200-133-6 can also cause gynecomastia.[5]
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