Question

I am a breastfeeding mother and i want to know if it is safe to use Sincalide? Is Sincalide safe for nursing mother and child? Does Sincalide extracts into breast milk? Does Sincalide has any long term or short term side effects on infants? Can Sincalide influence milk supply or can Sincalide decrease milk supply in lactating mothers?

Answer by DrLact: About Sincalide usage in lactation

Sincalide is a synthetic octapeptide analogue of cholecystokinin. Because sincalide has a molecular weight of 1143, the amount in milk is likely to be very low and oral absorption by the infant is unlikely because it is probably destroyed in the infant's gastrointestinal tract. The serum half-life of sincalide is less than 2 minutes, indicating that withholding breastfeeding for 10 minutes after a dose should ensure that the infant is not exposed to the drug.
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